Protein Info for Echvi_2383 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Highly conserved protein containing a thioredoxin domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03190: Thioredox_DsbH
  • amino acids 6 to 158 (153 residues), 232 bits, E=3.8e-73
• PF13899: Thioredoxin_7
  • amino acids 25 to 113 (89 residues), 38.2 bits, E=1.3e-13

Best Hits

KEGG orthology group: K06888, (no description) (inferred from 52% identity to dfe:Dfer_0027)

Predicted SEED Role

"Thymidylate kinase (EC 2.7.4.9)" (EC 2.7.4.9)

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
• superpathway of pyrimidine deoxyribonucleoside salvage (9/9 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (7/8 steps found)
• pyrimidine deoxyribonucleotide phosphorylation (4/4 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (11/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis II (4/7 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.4.9

Sequence Analysis Tools

See L0G0V7 at UniProt or InterPro

Protein Sequence (678 amino acids)

>Echvi_2383 Highly conserved protein containing a thioredoxin domain (Echinicola vietnamensis KMM 6221, DSM 17526)
MSPKANHLIDSQSPYLLQHAYNPVQWYPWGPEALDKAKLENKPIIVSIGYSACHWCHVME
HESFEDEATAKIMNAHFVCIKIDREERPDLDNIYMDAVQSMGLQGGWPLNVFLMPNQKPF
YGGTYFPNPNWKGLLQNIAEAYATHHDELAKSAEGFGNSIKLKEREKYRLADDPSRLTAE
DLTHMAQKIASQMDPQWGGFNRSPKFPMPAVWDFLLRYAALKGDASLIEKVLFTLTKIGM
GGIYDHLRGGFARYSVDSEWFAPHFEKMLYDNGQLLSLYAKAFQLSGDALFKEKINETVN
WLQAEMLQEEGGFYAALDADSEGEEGKFYTWTHDELESMLDDEDAWFYECFNISEKGNWE
KGVNILFQTHTYEEIAHKHGLEEEQLAQNLNEVKERLLKIRNLRTPPGLDDKVIAGWNGL
TISGLAQAYWATANPLAKSLAIQNGTFILDHMLKGEQLYRSYKNGEAYTPAFLEDYAAII
QGFIHLYQLTSEPRWLLVAKRLTAFVLEHFFDEDDGLFYFNNPDSETLIANKKEIFDNVI
PSSNALMATNLHQLGRYFYEDRYLALSRDLLGLMRKLLLSDPAFLSQWGSLYLSEYVGTP
EVAIVGKGAASLASELLQASPALKVIAAAENKSEDIPLLADKVADQNGNALIYVCFDKTC
LRPVATVAEAIDQFPTLK