Protein Info for Echvi_2012 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 454 PF05896: NQRA_N" amino acids 5 to 99 (95 residues), 106.8 bits, see alignment E=7.9e-35 TIGR01936: NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit" amino acids 5 to 450 (446 residues), 450.6 bits, see alignment E=3.1e-139 PF24836: NQRA_2nd" amino acids 118 to 262 (145 residues), 168.2 bits, see alignment E=2e-53 PF11973: NQRA_SLBB" amino acids 269 to 317 (49 residues), 58 bits, see alignment 1.6e-19

Best Hits

Swiss-Prot: 35% identical to NQRA_TOLAT: Na(+)-translocating NADH-quinone reductase subunit A (nqrA) from Tolumonas auensis (strain DSM 9187 / TA4)

KEGG orthology group: K00346, Na+-transporting NADH:ubiquinone oxidoreductase subunit A [EC: 1.6.5.-] (inferred from 64% identity to mtt:Ftrac_1554)

Predicted SEED Role

"Na(+)-translocating NADH-quinone reductase subunit A (EC 1.6.5.-)" in subsystem Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes (EC 1.6.5.-)

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.-

Use Curated BLAST to search for 1.6.5.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G061 at UniProt or InterPro

Protein Sequence (454 amino acids)

>Echvi_2012 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit (Echinicola vietnamensis KMM 6221, DSM 17526)
MSKLVKLKKGFDIKLEGKAEKKTEAFPPAQTFAIKPTDFVGMQRPKVTVKEGDTVKAGTP
ILFDKKLESVLYAAPVSGEIVEIKRGEKRKLLEIKIMADKEISYEEFSKFSESDLKSLTK
EQATDALLKGGVWPQIIQRPFGIVANPEDEPKAIFISGFDSHPLAPDYGVLLKGQEKYFQ
AGLNTLKKLTSGKVHLNLDQDSEVSPVYAGAQGVEVNKFSGPHPAGNVGVQIHHLDPINK
GEVAWTINPYGVVQIGKLLLEGIYDASKVVAITGSEAKKAVYAKTYQGACVDKLVAGNTK
SDHFRVVSGNVLTGERINHDGYLGYYDHQITLLPEGDYYEFMGWAKPTSSKLSFHRALGL
LSFLSPNKEYVLDTNTRGEERAFVQTGVFEQVTPMDIFPIYLLKAIMAEDFDEMEELGIY
EIIEEDLALCEFIDVSKHPVQDIVRKGIELIQYS