Protein Info for Echvi_1403 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: RND family efflux transporter, MFP subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 503 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 220 to 487 (268 residues), 112.2 bits, see alignment E=1.2e-36 PF13437: HlyD_3" amino acids 309 to 358 (50 residues), 26.7 bits, see alignment 7.7e-10

Best Hits

KEGG orthology group: None (inferred from 67% identity to rbi:RB2501_01101)

Predicted SEED Role

"Probable Co/Zn/Cd efflux system membrane fusion protein" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FY41 at UniProt or InterPro

Protein Sequence (503 amino acids)

>Echvi_1403 RND family efflux transporter, MFP subunit (Echinicola vietnamensis KMM 6221, DSM 17526)
MRYIIVLLSLVVISCQSTEEHGHAHDQEGGHSHAGEEKPSVDYTIWTDQTELFVEFPALV
VGESSRFATHFTVLDGHQPVREGTVTVSLIKGNKGIRHSVDAPSSPGIFVPSLQPKESGI
YQLIFELETPAYTDRIVLNDIPIFATAEEAEKVLAGEEENGNAITFLKEQAWKMEFQTAP
VLKKEVYQTIPTSGIWKVAPSDYQTLVAPATGRVSFSSGVLTEGSPVKEGQVLMTVSSTG
LTSNNLGAEIQKARADYEQAKSEYERKKELYESKIVPKSEFEQVEQKYQIAKTNYETLSS
GYSGGGKQVTAPIGGFIKSIQAVNGGFANQGDALVTVTSHKSSLLEVQVSPKYSAELKNI
RNIWYQPKEGAWSNLNEKGGKILSVDKEVEANQPLISVFAEVNEGVEMPEGSFTEAQLAV
GSAMESLVIPVSCLMEDYGNYSVIVQLSGESFERRNVTLGKRNGSEVEIIKGLSFGEVVV
TKGAYQVKMASMSGQAPAHGHAH