Protein Info for Echvi_1300 in Echinicola vietnamensis KMM 6221, DSM 17526
Annotation: delta-1-pyrroline-5-carboxylate dehydrogenase, group 1
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 55% identical to PUT2_AGABI: Delta-1-pyrroline-5-carboxylate dehydrogenase (pruA) from Agaricus bisporus
KEGG orthology group: K00294, 1-pyrroline-5-carboxylate dehydrogenase [EC: 1.5.1.12] (inferred from 73% identity to mtt:Ftrac_3126)MetaCyc: 49% identical to Delta1-pyrroline-5-carboxylate dehydrogenase, mitochondrial subunit (Homo sapiens)
RXN-14116 [EC: 1.2.1.88]; 1.2.1.- [EC: 1.2.1.88]
Predicted SEED Role
"Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12)" in subsystem Arginine and Ornithine Degradation or Proline, 4-hydroxyproline uptake and utilization (EC 1.5.1.12)
MetaCyc Pathways
- L-arginine degradation I (arginase pathway) (3/3 steps found)
- L-proline degradation I (3/3 steps found)
- trans-4-hydroxy-L-proline degradation I (4/5 steps found)
- ethene biosynthesis II (microbes) (1/4 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.88 or 1.5.1.12
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0FXV6 at UniProt or InterPro
Protein Sequence (543 amino acids)
>Echvi_1300 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1 (Echinicola vietnamensis KMM 6221, DSM 17526) MLKGFFNVPEPKNEPVFDYAPGTPARAKLQAALQEARSKEVDVPMYIGSEEVRTGNKIPL SPPHDHQHLLGHFHEGDKSHVEQAINAALGAKEAWETMEWEQRAAIFLKAADLIAGPYRY KMNAATMLGQSKNAFQAEIDSACEIVDFLRFNVKYMTEIYKQQPPISGDGVWNRLEQRPL EGFVFALTPFNFTAIAGNLPTAPAMMGNTVVWKPAYTQIYTANLLMQVFREAGVPDGVIN LVYVDGPAAGEVIFEHPEFAGIHFTGSTAVFQTIWKTIGNNIEKYKSYPRIVGETGGKDF VIAHKSADAKQLATGLVRGAFEFQGQKCSAASRAYIPSNLWEDVKKYMQEDLASIKMGGP EDFSNFINAVIDEKSFDKIAKYIDTAKSDGLEVVAGGHYDKSKGYFVEPTVLLTKDPMYT TMCEEIFGPVLTIYVYQEDHFEEALELVDQTSPYGLTGAIFSHDRYAAQLATQKLRNAAG NFYINDKPTGAVVGQQPFGGARKSGTNDKAGAMINMLRWVSPRTIKETFVTPTDYRYPFL GED