Protein Info for Echvi_0987 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Molecular chaperone, HSP90 family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 627 PF13589: HATPase_c_3" amino acids 29 to 138 (110 residues), 40.5 bits, see alignment E=4.1e-14 PF02518: HATPase_c" amino acids 30 to 176 (147 residues), 29.8 bits, see alignment E=1.1e-10 PF00183: HSP90" amino acids 208 to 622 (415 residues), 181.1 bits, see alignment E=6.6e-57

Best Hits

Swiss-Prot: 54% identical to HTPG_PORGI: Chaperone protein HtpG (htpG) from Porphyromonas gingivalis (strain ATCC BAA-308 / W83)

KEGG orthology group: K04079, molecular chaperone HtpG (inferred from 78% identity to phe:Phep_0051)

Predicted SEED Role

"Chaperone protein HtpG" in subsystem Protein chaperones

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FW40 at UniProt or InterPro

Protein Sequence (627 amino acids)

>Echvi_0987 Molecular chaperone, HSP90 family (Echinicola vietnamensis KMM 6221, DSM 17526)
MQEKGTISIHTENIFPIIKKFLYSDNEIFLRELVSNAVDATQKVKRLATLGQYAGELGDL
TVEVSFDKEKKTITIADKGLGMTAEEIKKYINQIAFSGATEFVEKFKDAKDANEIIGKFG
LGFYSAFMVAHRVDIHSLSYQEGAEPAKWTCDGSTSFEISQGDRTERGTEIVLHINEESE
EFLDKWKLQEILDKYCKFLPIPIKFETKTENVEDGKDEEGKPTYKSVEVDNIINTTEPIW
TKAPSDLKDEDYLAFYKELYPMSEDPLFWIHLNVDYPFNLTGVLYFPKVKNEFELQRNKI
KLFSRQVFITDEVKDIVPEFLMLLHGVIDSPDIPLNVSRSFLQADGNVKKINSYITKKVA
DKLAELFKKDRASYESKWNDIGLFVKYGMVSEDKFYDKGKDFALLKNTKDEYFTIAEYQE
KVKATQTDKDDQTIFLYSTDPEKQDTFIQSANAKDYDVLVLDSPIDSHFINNLEQKLEKT
SLKRVDADVADKLIKKEDSTSNVLTEEQSKTVKEVFEKAIANQSYAVEVEGLSPDELPVT
ITMEEFMRRMKDMAQTGGGMGFYGAMPDNYKVAINGNHKIIDKILKAEGEEEKTRLAKQA
FDLAKLSQGMLSGKDLTEFVKRSVDLI