Protein Info for Echvi_0773 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: 2-oxoglutarate dehydrogenase, E1 component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 932 PF16078: 2-oxogl_dehyd_N" amino acids 5 to 42 (38 residues), 49.5 bits, see alignment (E = 4.9e-17) TIGR00239: oxoglutarate dehydrogenase (succinyl-transferring), E1 component" amino acids 6 to 928 (923 residues), 1092.4 bits, see alignment E=0 PF00676: E1_dh" amino acids 207 to 524 (318 residues), 191.4 bits, see alignment E=3.8e-60 PF02779: Transket_pyr" amino acids 594 to 787 (194 residues), 155.7 bits, see alignment E=1.9e-49 PF16870: OxoGdeHyase_C" amino acids 793 to 929 (137 residues), 155.2 bits, see alignment E=2.2e-49

Best Hits

KEGG orthology group: K00164, 2-oxoglutarate dehydrogenase E1 component [EC: 1.2.4.2] (inferred from 64% identity to sli:Slin_5027)

Predicted SEED Role

"2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)" in subsystem TCA Cycle (EC 1.2.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FVL4 at UniProt or InterPro

Protein Sequence (932 amino acids)

>Echvi_0773 2-oxoglutarate dehydrogenase, E1 component (Echinicola vietnamensis KMM 6221, DSM 17526)
MDKYSYISNAHVAYIDELYEDYKKDPESIEPSWKTFFDGFDFAITKFGEDEDGGAVSGGS
SNGAAKNGALATKGTIMDMEQLPKEIKVRALIHAYRSRAHLRSKTNPVRERRDRKALIDL
EDFGLSEADLNTEFQAGNEIGIGDAKLSKILESLRKIYEGTMGFEYLYIRDPEMLDWFRQ
KIEKEALAFNPPDEEKKRILYKLNEAVVFENFLHTKYLGQKRFSLEGGESTIPFLDAVIN
KSADLGAEEVMIGMAHRGRLNVLANVMGKTYEQIFSEFEGTAKPDLTMGDGDVKYHMGFS
SEITTPSDKKINLKLAPNPSHLEAVNPVVEGFVRAKIDHQYEGDKDKVVPILIHGDAAVA
GQGIVYEVTQMANLKGYNTGGTIHFVINNQVGFTTDFDDARSSIYCTDVAKIIDAPVIHV
NGDDPEAVVFAAKLAADFRQRYNQDIFIDMVCYRRHGHNESDEPKFTQPNLYNIISKHPN
PREIYNKELMERGDVDAKLAKQMDKEFRKLLQDRLNMVKEKPLPYKSSPFEQAWKELRKS
EPADFDKSPDTYISEEAIEKVAEALTSLPKGFKPIKQIEAQMKQRKDMFYSSKSLNWAAA
ELLAYGSLLLEGKTVRLTGQDCRRGTFSHRHAVLHDANTNKSYNSLKEMKDNKGQFHIYN
SLLSEYAVLGFEYGYAMANPNALTIWEAQFGDFANGAQTMIDQFISSGESKWQKMNGLVM
LLPHGYEGQGPEHSNARPERFLQLSAEYNMVVANITEPSNFFHLLRRQLAWEFRKPCIVM
SPKSLLRHPKVVSPIDEFTKGGFREVLNDTTVKKTDVTRVVLCSGKIYYDLIEAREKEKV
KDVAIVRVEQLHPLPEKQIVEVVKSYSKNKEVVWVQEEPENMGYWTYMMRALFRDFPMDV
IARKASASPATGYFKVHQEEQEHIINKALKIK