Protein Info for Echvi_0744 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: glycine dehydrogenase (decarboxylating)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 966 transmembrane" amino acids 331 to 351 (21 residues), see Phobius details amino acids 752 to 771 (20 residues), see Phobius details PF02347: GDC-P" amino acids 13 to 441 (429 residues), 596 bits, see alignment E=4.2e-183 amino acids 481 to 737 (257 residues), 37.6 bits, see alignment E=1.3e-13 TIGR00461: glycine dehydrogenase" amino acids 14 to 953 (940 residues), 1437.5 bits, see alignment E=0 PF21478: GcvP2_C" amino acids 782 to 902 (121 residues), 191.3 bits, see alignment E=4.7e-61

Best Hits

KEGG orthology group: K00281, glycine dehydrogenase [EC: 1.4.4.2] (inferred from 63% identity to cat:CA2559_07640)

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FWL9 at UniProt or InterPro

Protein Sequence (966 amino acids)

>Echvi_0744 glycine dehydrogenase (decarboxylating) (Echinicola vietnamensis KMM 6221, DSM 17526)
MKIDLTPSVKFEDRHNGPSANDVSEMLSKIGASSIDELIDQTIPKAIQLDQPLNLPEAKS
EAAFLKDFRKMAAKNKIYKSFIGLGYYDTITPGVILRNVLENPGWYTAYTPYQAEIAQGR
LEALVNFQTMVMDLTGMELANASLLDEGTAAAEAMNMLFATRPRDKKKATKFFVDEKVFI
QTKEILKTRALPIGVTLVEGSLNELNLEDPELYGVLLQYPNAEGEAIDYKALVEKAKQHN
VTTAFSADLLALTLLTPPGEMGADVVVGTTQRFGVPMGFGGPHAAYFATKDAYKRQVPGR
IIGISVDKDGNKAYRMALQTREQHIKRERATSNICTAQVLLAVMAGMYAVYHGPKGLKDI
ALKIHGLAKLTAQGLAKLGFEQENEHYFDTLKIKVDDVKQSKIKAFALSHEMNFRYEPGY
VYLAFDEAKTMEDVQEIIEVFARTTHSSADVVDLASMVDHLSFEVSDGLRRTSDYMDHMI
FNAFHSEHEMLRYIKRLENRDLSLVHSMISLGSCTMKLNATAEMIPVTWPEFGQLHPFVP
QDQAAGYYALFQDLRNWLSEITGFAETSLQPNSGAQGEFAGLMVIRAYHESRGESHRNIA
LIPSSAHGTNPASAVMAGMKVVIVKCDDKGNIDLADLKEKAEKHKENLSSFLVTYPSTHG
VFEEAIREMCQIVHENGGQVYMDGANMNAQVGLTSPGVIGADVCHLNLHKTFCIPHGGGG
PGMGPICVAKHLEEFLPSSPLVKTGGQQPISAISAAPFGSASILPISYAYIAMMGREGLK
HATQTAILNANYIKARLGEFFPTLYTGAQGRAAHEMIVDFREFKAVGVEVEDIAKRLIDY
GFHSPTVSFPVAGTMMIEPTESESKAELDRFCDALIAIRGEIREIEEGKADAENNVLKNA
PHTAGMVMSDAWDMPYSREKAVYPLEYVKNSKFWPTVRRIDSAYGDRNLVCSCIPTEDYA
EEAAGI