Protein Info for Echvi_0585 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 412 transmembrane" amino acids 20 to 39 (20 residues), see Phobius details amino acids 153 to 173 (21 residues), see Phobius details PF02518: HATPase_c" amino acids 293 to 394 (102 residues), 71.5 bits, see alignment E=4e-24

Best Hits

Predicted SEED Role

"sensor histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FV02 at UniProt or InterPro

Protein Sequence (412 amino acids)

>Echvi_0585 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (Echinicola vietnamensis KMM 6221, DSM 17526)
MRNKFQDLATLDLYQNRGKVKWIIFIASLIISIGSIYYTNTLVSELKEREKKQITLYANA
MEYVANNSDNLTFIHQGIIQENHNIPVIVADAFGKPSGEYRNITFKKNATEADIEEKLRS
EVLRMKMDYEPIQILDNQYLYYTNSELLTRLKYYPYVQLSVILVFGVLAFAVFNQSKIAE
QNRVWAGLTKETAHQLGTPIASLMAWIDYLKNSPVWDENKEVIVELDKDVSKLRMVTERF
SNIGSAPVIKQENVYSVIEEAVNYLRPRISSKVSIDLSSHAEDVDAMMNRSLFEWVVENI
CKNAVDAMKGQGQIAINIVKESEQFVHVDIADTGKGIDKSMFKRVFNPGFTTRQRGWGLG
LTLAKRIIEGYHKGRIFVHQSELGKGTTFRIVLRGANESSSEFKVDRDPFLD