Protein Info for Echvi_0577 in Echinicola vietnamensis KMM 6221, DSM 17526
Updated annotation (from data): Ornithine aminotransferase (EC 2.6.1.13)
Rationale: Specifically important for utilizing L-Arginine. Automated validation from mutant phenotype: the predicted function (ORNITHINE-GLU-AMINOTRANSFERASE-RXN) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
Original annotation: ornithine aminotransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 61% identical to OAT_DROAN: Ornithine aminotransferase, mitochondrial (Oat) from Drosophila ananassae
KEGG orthology group: K00819, ornithine--oxo-acid transaminase [EC: 2.6.1.13] (inferred from 73% identity to mtt:Ftrac_2019)MetaCyc: 61% identical to Ornithine aminotransferase (Homo sapiens)
Ornithine aminotransferase. [EC: 2.6.1.13]
Predicted SEED Role
"Ornithine aminotransferase (EC 2.6.1.13)" in subsystem Arginine and Ornithine Degradation or Dimethylarginine metabolism (EC 2.6.1.13)
MetaCyc Pathways
- L-citrulline biosynthesis (8/8 steps found)
- L-arginine degradation XIII (reductive Stickland reaction) (5/5 steps found)
- superpathway of L-citrulline metabolism (10/12 steps found)
- L-arginine degradation VI (arginase 2 pathway) (4/4 steps found)
- L-Nδ-acetylornithine biosynthesis (6/7 steps found)
- L-arginine degradation I (arginase pathway) (3/3 steps found)
- L-ornithine biosynthesis II (3/3 steps found)
- L-proline biosynthesis III (from L-ornithine) (3/3 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.6.1.13
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0FW07 at UniProt or InterPro
Protein Sequence (413 amino acids)
>Echvi_0577 Ornithine aminotransferase (EC 2.6.1.13) (Echinicola vietnamensis KMM 6221, DSM 17526) MMQPITSSQQAIELENKHGAHNYHPLPVVLSRGEGVFMWDVEGEKYYDFLSSYSAVNQGH CHPRILQTLIDQAGTLTLTSRAFHNDVLGPFEKFLTEYFGYDKVLPMNTGAEGVETAIKI ARKWGYEKKGIPENEGTIIVAKNNFHGRTTTVISFSNDETARKNFGPYTPGFVTIPHDDI DALKDVLSQSKNIIGYLVEPIQGEAGVYVPKEGYLKEVAAVCKDHGVLFMADEIQTGIAR TGKLLACDHEGVKPDMLILGKAISGGFYPVSAVLADDHIMEVIQPGQHGSTFGGNPLGAK VAMTALNVVKDEKLAENADKLGKLFRERIQQLVDKSDLVELVRGKGLLNAIVINDTEDSD TAWRLCLALKENGLLAKPTHGNIIRFAPPLVITEEQLHDCCDIIEKTIQNFKK