Protein Info for Echvi_0541 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1054 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 341 to 360 (20 residues), see Phobius details amino acids 367 to 388 (22 residues), see Phobius details amino acids 394 to 417 (24 residues), see Phobius details amino acids 437 to 460 (24 residues), see Phobius details amino acids 474 to 499 (26 residues), see Phobius details amino acids 542 to 557 (16 residues), see Phobius details amino acids 873 to 890 (18 residues), see Phobius details amino acids 897 to 919 (23 residues), see Phobius details amino acids 925 to 949 (25 residues), see Phobius details amino acids 974 to 997 (24 residues), see Phobius details amino acids 1004 to 1028 (25 residues), see Phobius details PF00873: ACR_tran" amino acids 1 to 1028 (1028 residues), 976.5 bits, see alignment E=1.5e-297 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 2 to 1032 (1031 residues), 1045.2 bits, see alignment E=0 PF03176: MMPL" amino acids 348 to 498 (151 residues), 28.1 bits, see alignment E=1e-10

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 84% identity to fjo:Fjoh_4408)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FVX3 at UniProt or InterPro

Protein Sequence (1054 amino acids)

>Echvi_0541 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family (Echinicola vietnamensis KMM 6221, DSM 17526)
MFQKFIHRPVFAIVISVIIVFVGTLAIKKLPISQFPQIAPTTVNVFIAYPGASADVLVKS
TLITLENSINGAQGMRYMATDATSAGEATLRVIFEPGTDPNQAVIRVKTRVDRVMPLLPE
LVQREGVIITPIQPSMLMYVNLYGTGKNMDEKFLYNYANVHMIPEINRIKGVAKAQILGS
RRYAMRIWLNPDRMRAYDISVEEVMEALQEQSIVGRPGRLGRSSGIEAQSLEYVLTYKGR
YNEPEQYENVIIRANAEGESIHLKDIGKVELGSEFFDIYSNLDGHPSAAIVLKQNYGSNA
SDVIETVKEKLTEMKETFPPGVDYKISYDVSNFLDASIEQVIHTLRDAFILVALVVFIFL
GDWRSTLIPILAVPVSLIGAFFVIQFFGLSINLVTLFALVLAIGIVVDDAIVVVEAVHAK
MEEFPRLTPYQAVKRVLGEISGAIIAITMVMVSVFLPISFMSGPVGTFYRQFSITMASSI
VISALIALTLTPVLCAMLLKNHHGKAKKGNLLTKSLDKFNSGFDKLTGRYVVLLKRMVSR
RWLTFGILIAFCAGIYLENQVLPSGFIPSEDQGTIYAIIQTPPGATLERTNKVSQELQKI
CEEIEGVESVSSLAGYEIMTEGRGSNAGTCLINLKKWSDRKHTVKEIMEELEEESKGLGA
VIEFFEPPAIPGFGSSGGFSMRLLDKTTDTDYQDFDKINKQFMDDLSKRKELTGLFTFFA
ANYPQYELVIDNELAMQKGVSIGKAMENLNIMIGSTYEQGFIKFGRFFKVYVQSDPKFRR
LPSDVLNLYVKNDEGEMVPYSAFMTLKKTQGPNEVTRFNMYNSAAIRGLPAKGYTTADAI
AAIREVAAQTLPQGYDIAWEGLSYDESNRGNESLYVFLVVLVFVYFVLAAQYESFIIPLA
VVTSLPVGVFGSFLLLKMMGLDNDIYAQIGLIMLIGLLGKNAVLIVEFAVQKRQQGATIL
DAAIEGAKVRFRPILMTSFAFIAGLIPLIIATGAGAIGNRTIGASALGGMLFGTVFGVII
VPGLYYIFGKLADGRHLIKDEDEVPLTEEYDYND