Protein Info for Echvi_0478 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: 6-phosphogluconate dehydrogenase, decarboxylating

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 636 transmembrane" amino acids 164 to 183 (20 residues), see Phobius details TIGR01313: carbohydrate kinase, thermoresistant glucokinase family" amino acids 3 to 155 (153 residues), 171 bits, see alignment E=1.7e-54 PF01202: SKI" amino acids 10 to 117 (108 residues), 34.2 bits, see alignment E=6.6e-12 TIGR00873: 6-phosphogluconate dehydrogenase (decarboxylating)" amino acids 167 to 630 (464 residues), 472.6 bits, see alignment E=1.4e-145 PF03446: NAD_binding_2" amino acids 167 to 340 (174 residues), 140.3 bits, see alignment E=1.5e-44 PF00393: 6PGD" amino acids 346 to 627 (282 residues), 287.6 bits, see alignment E=2.8e-89

Best Hits

Predicted SEED Role

"6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" in subsystem Pentose phosphate pathway (EC 1.1.1.44)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.44

Use Curated BLAST to search for 1.1.1.44

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FUQ6 at UniProt or InterPro

Protein Sequence (636 amino acids)

>Echvi_0478 6-phosphogluconate dehydrogenase, decarboxylating (Echinicola vietnamensis KMM 6221, DSM 17526)
MIILLMGVSGSGKTTIGRMLSGKVGLPFYDADDFHPKNNVEKMKAGIPLNDQDRVPWLET
LSEKMVAWEENGGAILACSALKASYRKMLRSHAVQMRWFFLKGDEALIAKRMKAREGHYM
PASLLSSQLETLEPPKHATIISIDQTPENILEDIMSDLKNNKAVSSFGIIGMGVMGSSLA
LNLAEKDVKISVYNRTLQGVEEDVAQKLVDAHPEVKGILPFDKLDEFVESLEQPRKILMM
IPAGQIVDQQIARLLTFVDKGDVIIDGGNSFFEDSAKRQQYLQGYGIHFVGMGISGGRDG
ALKGPSLMPGGSEEGFELIKPYLEKIAGKDKGGKPCMHYVGPDGAGHFIKMVHNSIEYGE
IQVLAELYGFMRKGLGMSIEEMVKTFKTWSKEGADSYLMDATLAILSHEKDGKLLLDGIL
DVAGQTGTGGWAVSTAAKYGVPYAPLTAAVTARLVSTHKEARVSFAQTYPRKTDEIDQKE
IIDALKGAYDMARLVNHEIGFSLIKKVGEAEKWGLNMSEIARCWTNGSIIQSSLMEKLAG
VFKSTDCLMASAALKASFENGAKTLAEVVGAGLKAGIAMPVMSAAINFFYGMSSGQSSAN
LVQALRDCFGEHGYRLVDDVSGKIHRNKWRKSKEEA