Protein Info for Echvi_0463 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Zinc metalloprotease (elastase)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 862 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF07504: FTP" amino acids 67 to 116 (50 residues), 62.1 bits, see alignment 6.9e-21 PF01447: Peptidase_M4" amino acids 245 to 398 (154 residues), 105.8 bits, see alignment E=5.8e-34 PF02868: Peptidase_M4_C" amino acids 411 to 573 (163 residues), 137.4 bits, see alignment E=8.8e-44 TIGR04183: Por secretion system C-terminal sorting domain" amino acids 781 to 858 (78 residues), 41.8 bits, see alignment E=4.1e-15 PF18962: Por_Secre_tail" amino acids 781 to 859 (79 residues), 48.8 bits, see alignment E=1.4e-16

Best Hits

Predicted SEED Role

"Thermolysin precursor (EC 3.4.24.27)" (EC 3.4.24.27)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.24.27

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FUN8 at UniProt or InterPro

Protein Sequence (862 amino acids)

>Echvi_0463 Zinc metalloprotease (elastase) (Echinicola vietnamensis KMM 6221, DSM 17526)
MRTITKLLVVVLFCLSTTFSNAQVRDTADVQYDRSGNISFVRVKAQSNQKMENAKALLAL
LLAGEHDDFKPVKEINDKFGMSHLKFQQYYKGIKVENSEYWVHGKNGKITKFNGHFRTID
IGSVQPQITEDAALSNALGFIDAEIYKWEDEGMQSFLREHSGDPTSSYYPEGELVITKNE
MKEGKEEEMILAWKFLISSMVPNDEQVIFVDAGSGDIVRAYSLTCEIRLETGRNIEEVNT
PSLAETMYSGNLSITSDSFAGGFRLREERDGVDIITLNLNNSDNIGTAADFSNTGTNWTS
GNWAGINQDQQALDVHWGAEMVADYWQTVHQRNSIDDSGIRILSYVHYTPNFDGSPINNA
FWQGGINARYMLYGDGDSGQPNPLTSLDICAHEFGHGINEFTANLTPGWHETGALNEGFS
DIWAACIEDWATSNKATWIMGEEVFSGGFNGLRNLQNPKSTNTAEGQHPDTYQGDYWHAQ
EEPHFNSTVLSHWFYLLSQGGSGTNDNNDSYTVDGIGLEKAALIAYRMELIYLTSSSEYA
DARIAAINAAEDIYCENSPEVRAVTDAWYAVGVGGAFSGGIMNISGEDIVCSNTSFSLSN
IPSGTNISWSVSPSNLVTSSSGSGATANLTPAASYSSGQATITYTVGNGTCETEIQKAIY
VHAGSPDEGNATYSYNGSNQTANPYISVINNIVCDLLYPVTLDVPLLGSEISNVSMIYTS
DPNITYWGSGGAESMSINFEFWEYGQEVIFRVSMQNDCGTSYQDYAFRSEDCYGTALNYK
VYPNPASESINIELDQDLIKQSVSDKEKVNIKLFDPSGTELMSKTVNESRTTIDVSNLGN
GFYYVHIIHKNGIIRKKLRIER