Protein Info for Echvi_0188 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: 3-oxoacyl-(acyl-carrier-protein) synthase III

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 332 transmembrane" amino acids 309 to 327 (19 residues), see Phobius details TIGR00747: 3-oxoacyl-[acyl-carrier-protein] synthase III" amino acids 5 to 327 (323 residues), 371.4 bits, see alignment E=1.8e-115 PF08392: FAE1_CUT1_RppA" amino acids 48 to 171 (124 residues), 29.9 bits, see alignment E=7.3e-11 PF00108: Thiolase_N" amino acids 51 to 154 (104 residues), 44 bits, see alignment E=3.8e-15 PF08545: ACP_syn_III" amino acids 110 to 188 (79 residues), 102.6 bits, see alignment E=1.7e-33 PF08541: ACP_syn_III_C" amino acids 240 to 327 (88 residues), 108.5 bits, see alignment E=3.1e-35

Best Hits

Swiss-Prot: 60% identical to FABH_PARD8: 3-oxoacyl-[acyl-carrier-protein] synthase 3 (fabH) from Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)

KEGG orthology group: K00648, 3-oxoacyl-[acyl-carrier-protein] synthase III [EC: 2.3.1.180] (inferred from 76% identity to mtt:Ftrac_3199)

Predicted SEED Role

"3-oxoacyl-[acyl-carrier-protein] synthase, KASIII (EC 2.3.1.180)" (EC 2.3.1.180)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.180

Use Curated BLAST to search for 2.3.1.180

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FUY3 at UniProt or InterPro

Protein Sequence (332 amino acids)

>Echvi_0188 3-oxoacyl-(acyl-carrier-protein) synthase III (Echinicola vietnamensis KMM 6221, DSM 17526)
MEKTRAVITGVNGWVPDYVLTNKELESMVETSDEWITSRTGIKERRILKGEDKATSDIGA
NAIKGLLEKTNTNPEDIDLIICATVTPDMPFPSCANMISHKVGAKNSYSFDISAACSGFI
YALTIGSQFIETGMHKKVIVVGADKMSSIVNYEDRTTCIIFGDGGGAVLLEPTTEEVGVM
DSLHHSDGSGSPYLHIKAGGSLKPASEDTVKAKEHYAYQEGSTVFKFAVTNMAEVSAQIM
AKNNLKGDDIAWLVPHQANKRIIDATANRMNVGPEKVMINIEKYGNTTAGTIPLCLWDYE
SKLKKGDNIILAAFGGGFTWGSVYLKWGYDPK