Protein Info for Echvi_0181 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Phosphoglycerate dehydrogenase and related dehydrogenases

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 311 PF00389: 2-Hacid_dh" amino acids 3 to 219 (217 residues), 99.9 bits, see alignment E=1.9e-32 PF02826: 2-Hacid_dh_C" amino acids 105 to 286 (182 residues), 164.3 bits, see alignment E=3.9e-52 PF07991: IlvN" amino acids 137 to 215 (79 residues), 25 bits, see alignment E=2.6e-09 PF03446: NAD_binding_2" amino acids 141 to 243 (103 residues), 25.7 bits, see alignment E=2.2e-09

Best Hits

KEGG orthology group: K00058, D-3-phosphoglycerate dehydrogenase [EC: 1.1.1.95] (inferred from 56% identity to sli:Slin_0324)

Predicted SEED Role

"D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)" in subsystem Glycine and Serine Utilization or Pyridoxin (Vitamin B6) Biosynthesis or Serine Biosynthesis (EC 1.1.1.95)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.95

Use Curated BLAST to search for 1.1.1.95

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FTX2 at UniProt or InterPro

Protein Sequence (311 amino acids)

>Echvi_0181 Phosphoglycerate dehydrogenase and related dehydrogenases (Echinicola vietnamensis KMM 6221, DSM 17526)
MNILIIDEMHSSIIPLLEEKGFKVNYSPKITREEIEAIIADYEGLIIRSKTPMDKPLLEK
AKKLKFIGRAGAGLDKIDLDFIQKQGIKLFHAPEGNRDAVGEHAVAMLLMLFNNLKKADS
EVRQGVWDREGNRGEELQGKTVGIFGYGNMGKAFARRLSGFGVKVVAYDKYLDKYSDEYA
AQVTFDQLQQQADVLSIHVPLTEETRNFFTEEVLAGFSKPFYLINTARGEVISMETLNAA
LEKGILKGALLDVLENEKLHTLNDVQKTAFEKLSVRDDVLFSPHIAGWTFQSYKKINEVL
VSKISEAFLVK