Protein Info for Echvi_0160 in Echinicola vietnamensis KMM 6221, DSM 17526
Annotation: Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 59% identical to PCCB_MOUSE: Propionyl-CoA carboxylase beta chain, mitochondrial (Pccb) from Mus musculus
KEGG orthology group: K01966, propionyl-CoA carboxylase beta chain [EC: 6.4.1.3] (inferred from 80% identity to mtt:Ftrac_3157)MetaCyc: 64% identical to propionyl-CoA carboxylase beta chain, mitochondrial (Homo sapiens)
Propionyl-CoA carboxylase. [EC: 6.4.1.3]
Predicted SEED Role
"Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) / Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2); Propionyl-CoA carboxylase beta chain (EC 6.4.1.3)" in subsystem Fatty Acid Biosynthesis FASII (EC 6.4.1.2, EC 6.4.1.3)
MetaCyc Pathways
- propanoyl CoA degradation I (3/3 steps found)
- 2-oxobutanoate degradation I (3/4 steps found)
- fatty acid biosynthesis initiation (type I) (1/3 steps found)
- anaerobic energy metabolism (invertebrates, mitochondrial) (6/10 steps found)
- superpathway of anaerobic energy metabolism (invertebrates) (10/17 steps found)
- 3-hydroxypropanoate cycle (7/13 steps found)
- superpathway of L-methionine salvage and degradation (9/16 steps found)
- methylaspartate cycle (11/19 steps found)
- 3-hydroxypropanoate/4-hydroxybutanate cycle (10/18 steps found)
- jadomycin biosynthesis (3/9 steps found)
- superpathway of the 3-hydroxypropanoate cycle (7/18 steps found)
- mycolate biosynthesis (23/205 steps found)
- superpathway of mycolate biosynthesis (24/239 steps found)
KEGG Metabolic Maps
- Fatty acid biosynthesis
- Propanoate metabolism
- Pyruvate metabolism
- Tetracycline biosynthesis
- Valine, leucine and isoleucine degradation
Isozymes
Compare fitness of predicted isozymes for: 6.4.1.2
Use Curated BLAST to search for 6.4.1.2 or 6.4.1.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0FT37 at UniProt or InterPro
Protein Sequence (527 amino acids)
>Echvi_0160 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) (Echinicola vietnamensis KMM 6221, DSM 17526) MKSATKGVYTLPGNKEKLELLKKKNEEALMGGGQQRIATQHEKGKLTARERIHLLIDEGT FQEIDKFKMHRCKDFGLDKEYYLGDGVVTGYGEVNGRLVYVYSQDFTVFGGSLSETHAEK ICKIMDMAMKNGAPVIGLNDSGGARIQEGVNSLGGYADIFYRNTRASGVIPQLSAIMGPC AGGAVYSPAITDFILMVEETSYMFVTGPNVVKTVTQEHVSSEELGGASTHSTKSGVTHFA CQNEVECIKTIKDILSYIPQNCEDDAPSYPYDMLEDESRPVLDTMVPENPNHPYDMREVV RGIVDEASFLEVHQNFADNMVVGFARIAGRSIGVVGNQPQSLAGVLDNDASIKAARFVRF CDCFNVPLLVLVDVPGFLPGTDQEWNGIITNGAKLLYAFSEATVPRITVITRKAYGGAYD VMNSKHIGADLNFAWPTAEIAVMGAKGAAEIIFKKEIAQAEDSEAKLQEKIDQYTRKFAN PYKAAHRGYIDEVILPSQTRKKLISGFKMLKNKVDNLPKKKHGNIPL