Protein Info for Echvi_0003 in Echinicola vietnamensis KMM 6221, DSM 17526
Annotation: LAO/AO transport system ATPase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 47% identical to Y1533_MYCBO: Probable GTPase Mb1533 (BQ2027_MB1533) from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
KEGG orthology group: K07588, LAO/AO transport system kinase [EC: 2.7.-.-] (inferred from 48% identity to din:Selin_2359)MetaCyc: 44% identical to methylmalonyl-CoA mutase-interacting GTPase YgfD (Escherichia coli K-12 substr. MG1655)
3.6.1.15,3.6.5.6,3.6.5.5,3.6.5.4,3.6.5.3,3.6.5.2,3.6.5.1,3.6.1.-,3.6.1.5 [EC: 3.6.1.15, 3.6.1.5, 3.6.5.1, 3.6.5.2, 3.6.5.3, 3.6.5.4, 3.6.5.5, 3.6.5.6]
Predicted SEED Role
"putative periplasmic protein kinase ArgK and related GTPases of G3E family"
MetaCyc Pathways
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
- pyrimidine deoxyribonucleotides biosynthesis from CTP (7/8 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (11/14 steps found)
- UTP and CTP dephosphorylation I (5/7 steps found)
- UTP and CTP dephosphorylation II (1/3 steps found)
KEGG Metabolic Maps
- Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
- Lipopolysaccharide biosynthesis
- Purine metabolism
- Pyrimidine metabolism
- Thiamine metabolism
Isozymes
Compare fitness of predicted isozymes for: 3.6.1.15
Use Curated BLAST to search for 2.7.-.- or 3.6.1.15 or 3.6.1.5 or 3.6.5.1 or 3.6.5.2 or 3.6.5.3 or 3.6.5.4 or 3.6.5.5 or 3.6.5.6
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0FSN3 at UniProt or InterPro
Protein Sequence (334 amino acids)
>Echvi_0003 LAO/AO transport system ATPase (Echinicola vietnamensis KMM 6221, DSM 17526) MSRSKHKRLDPAAYAEGVLSGDRSMLSKTITLIESKLEEDQVLAERVLQLLLPHTGKAKR IGVTGAPGVGKSTFIEAFGKVILQGGHRLAVLSIDPSSKQSGGSILGDKTRMEELSKSPN AYIRPSPGGGYAGGVAISTREAMLVCEAAGYDVVIVETIGVGQSEVQVKEMVDFFMLIVQ PETGDGLQGVKRGIMEMVDTIVVNKADERSRQSAAQTKRELEGACQLMSPRSGAGQITVL LVSSVEKRGLEEVWAVTQEFFGKISATGFLGENRKAQRNHWFYAHVQKALEQRFYQDPHV VTKIEEALGEVKDAKELPAAVARNLVNTFFKASD