Protein Info for EX28DRAFT_3744 in Enterobacter asburiae PDN3

Annotation: Chloride channel protein EriC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 466 transmembrane" amino acids 33 to 53 (21 residues), see Phobius details amino acids 76 to 97 (22 residues), see Phobius details amino acids 127 to 146 (20 residues), see Phobius details amino acids 177 to 201 (25 residues), see Phobius details amino acids 213 to 232 (20 residues), see Phobius details amino acids 252 to 271 (20 residues), see Phobius details amino acids 291 to 308 (18 residues), see Phobius details amino acids 319 to 342 (24 residues), see Phobius details amino acids 345 to 348 (4 residues), see Phobius details amino acids 355 to 375 (21 residues), see Phobius details amino acids 388 to 412 (25 residues), see Phobius details amino acids 421 to 439 (19 residues), see Phobius details PF00654: Voltage_CLC" amino acids 90 to 436 (347 residues), 316.3 bits, see alignment E=1.4e-98

Best Hits

Swiss-Prot: 84% identical to CLCA_SALAR: H(+)/Cl(-) exchange transporter ClcA (clcA) from Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

KEGG orthology group: K03281, chloride channel protein, CIC family (inferred from 97% identity to enc:ECL_00959)

MetaCyc: 74% identical to chloride:H+ antiporter ClcA (Escherichia coli K-12 substr. MG1655)
RXN0-2501

Predicted SEED Role

"H(+)/Cl(-) exchange transporter ClcA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (466 amino acids)

>EX28DRAFT_3744 Chloride channel protein EriC (Enterobacter asburiae PDN3)
MKSDSPSFEEQQFTRAQHRISIRRLLNRDKTPLAILLAAAVVGTLAGLVGVAFEKAVNAV
LNWRVGTVAGFADSEWLVWVWAFGLSALFAMVGYFLVRKFAPEAGGSGIPEIEGALEELR
PVRWWRVIPVKFIGGMGTLGAGMVLGREGPTVQLGGNVGRMVGDLFRMRSAEARHTLLAT
GAAAGLSAAFNAPLAGILFIIEEMRAQFRYNLISIKAVFTGVIMSSIVFRIFNGEGAVIE
VGKLTNAPVNTLWLYLILGMIFGVVGPLFNTFILRAQDMFQRIHGGNTTKWVLMGGLLGG
MCGVLGFIEPNAAGGGFGLIPIAAAGNFSVGLLLFMFISRVITTVLCFSSGAPGGIFAPM
LALGTLLGTAFGMAAEVGFPAYHLEAGTFAVAGMGALLAASLRAPLTGIVLVLEMTDNYQ
LILPMIITCLGATLLAQFLGGKPLYSTILACTLAKQEAERAATQNT