Protein Info for EX28DRAFT_0994 in Enterobacter asburiae PDN3

Annotation: Transcriptional regulator of aromatic amino acids metabolism

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 513 PF00158: Sigma54_activat" amino acids 206 to 365 (160 residues), 189.7 bits, see alignment E=6.9e-60 PF14532: Sigma54_activ_2" amino acids 209 to 370 (162 residues), 69.9 bits, see alignment E=5.5e-23 PF00004: AAA" amino acids 230 to 347 (118 residues), 22.3 bits, see alignment E=3.1e-08 PF18024: HTH_50" amino acids 458 to 507 (50 residues), 68 bits, see alignment 9e-23 TIGR04381: TyrR family helix-turn-helix domain" amino acids 460 to 507 (48 residues), 94.7 bits, see alignment 1.2e-31

Best Hits

Swiss-Prot: 88% identical to TYRR_SALTY: Transcriptional regulatory protein TyrR (tyrR) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03721, transcriptional regulator of aroF, aroG, tyrA and aromatic amino acid transport (inferred from 98% identity to enc:ECL_01794)

Predicted SEED Role

"Transcriptional repressor protein TyrR" in subsystem Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) or Phenylalanine and Tyrosine Branches from Chorismate

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (513 amino acids)

>EX28DRAFT_0994 Transcriptional regulator of aromatic amino acids metabolism (Enterobacter asburiae PDN3)
MRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPVGRIYLNFAEIEFNTFSSLMAEIRR
IAGVTDVRTIPWMPSEREHLALSALLEAMPEPFLSLDLKSKVERVNHASCQLFAQSQEKL
SNHNAAQLIPGFNFQRWLDSNPQNTLSEHMVINGQNFLMEITPVYLKGEGNTRVLTGAVI
MLRSTLRMGRQLQNLSSQDVGAFSQIIAVSPKMRHVVDQARKLASLTAPLLITGDTGTGK
DLLAHAVHLASPRAAKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEI
GEMSPRMQAKLLRFLNDGTFRRVGEDHEVHVDVRVICATQKNLVELVQKGIFREDLYYRL
NVLTLNIPPLRDCPQDIMPLTELFVARFADEQGVPRPKLSADLGTVLMRYGWPGNIRQLK
NAVYRALTQLEGYELRPQDILLPDYDAGTVSVGEEAMEGSLEDITSRFERSVLTQLYRSY
PSTRKLAKRLGVSHTAIANKLREYGLNHKKGDE