Protein Info for EX28DRAFT_0482 in Enterobacter asburiae PDN3

Annotation: Cation/multidrug efflux pump

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1025 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 336 to 353 (18 residues), see Phobius details amino acids 360 to 384 (25 residues), see Phobius details amino acids 390 to 410 (21 residues), see Phobius details amino acids 431 to 451 (21 residues), see Phobius details amino acids 463 to 490 (28 residues), see Phobius details amino acids 527 to 546 (20 residues), see Phobius details amino acids 561 to 571 (11 residues), see Phobius details amino acids 853 to 871 (19 residues), see Phobius details amino acids 891 to 917 (27 residues), see Phobius details amino acids 953 to 970 (18 residues), see Phobius details amino acids 982 to 1008 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1008 (1005 residues), 1215.8 bits, see alignment E=0 PF03176: MMPL" amino acids 329 to 501 (173 residues), 24.1 bits, see alignment E=2.5e-09 PF02355: SecD_SecF_C" amino acids 338 to 484 (147 residues), 22.5 bits, see alignment E=1.1e-08

Best Hits

Swiss-Prot: 95% identical to MDTC_ENT38: Multidrug resistance protein MdtC (mdtC) from Enterobacter sp. (strain 638)

KEGG orthology group: K07789, RND superfamily, multidrug transport protein MdtC (inferred from 61% identity to bav:BAV3041)

MetaCyc: 92% identical to multidrug efflux pump RND permease subunit MdtC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-353; TRANS-RXN-92

Predicted SEED Role

"Multidrug transporter MdtC"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1025 amino acids)

>EX28DRAFT_0482 Cation/multidrug efflux pump (Enterobacter asburiae PDN3)
MKFFALFIYRPVATILISLAITLCGVLGFRLLPVAPLPQVDFPVIMVSASLPGASPETMA
SSVATPLERSLGRIAGVNEMTSSSSLGSTRIILEFSFDRDINGAARDVQAAINAAQSLLP
SGMPSRPTYRKANPSDAPIMILTLTSDTYSQGQLYDFASTQLAQTISQINGVGDVSVGGS
SLPAVRVGLNPQALFNQGVSLDDVRSAISTANVRKPQGAIEDGSHRWQIHTNDELKTAAE
YQPLIIHYNNGAAVRLSDVASVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIETVNSI
RARLPDLQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATL
IPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENISRHLEAGVKP
LQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLVISLT
LTPMMCGWMLKRSKPHSQPRRKGFGRLLMAMQEGYGKSLKWVLNHTRLVGLVLIGTIVLN
VWMYITIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIREDKAVDNVTGFTG
GSRVNSGMMFITLKPRGERNETAQQVIDRLRVKLAKEPGANLFLMAVQDIRVGGRQANAS
YQYTLLSDDLAALREWEPKIRKALAALPELADVNSDQQDNGAEMALTYDRETMSRLGINV
EAANSLLNNAFGQREISTIYQPMNQYKVVMEVDPRYTQDISALDKMFVINNDGKAIPLSY
FASWQPANAPLSVNHQGLSAASTISFNLPAGSSLSEASDAINRAMTQLGVPSTVRGSFAG
TAQVFQETMNSQVILILAAIATVYIVLGVLYESYVHPLTILSTLPSAGVGALLALELFGA
PFSLIALIGIMLLIGIVKKNAIMMVDFALDAQRNGNLSPEEAIFQACLLRFRPIMMTTLA
ALFGALPLVISGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKNR
TTVTE