Protein Info for EX28DRAFT_0139 in Enterobacter asburiae PDN3

Annotation: inosine-5'-monophosphate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01302: inosine-5'-monophosphate dehydrogenase
  • amino acids 8 to 454 (447 residues), 656.6 bits, E=1e-201
• PF00478: IMPDH
  • amino acids 8 to 473 (466 residues), 534.9 bits, E=1.6e-164
• PF00571: CBS
  • amino acids 95 to 140 (46 residues), 35.6 bits, 1.9e-12
  • amino acids 153 to 204 (52 residues), 24.3 bits, 6.6e-09
• PF01070: FMN_dh
  • amino acids 278 to 362 (85 residues), 31.8 bits, E=1.7e-11

Best Hits

Swiss-Prot: 96% identical to IMDH_ECOLI: Inosine-5'-monophosphate dehydrogenase (guaB) from Escherichia coli (strain K12)

KEGG orthology group: K00088, IMP dehydrogenase [EC: 1.1.1.205] (inferred from 99% identity to enc:ECL_03845)

MetaCyc: 96% identical to inosine 5'-monophosphate dehydrogenase (Escherichia coli K-12 substr. MG1655)
IMP dehydrogenase. [EC: 1.1.1.205]

Predicted SEED Role

No annotation

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (46/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (26/26 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotide salvage (13/14 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis II (8/8 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
• guanosine ribonucleotides de novo biosynthesis (4/4 steps found)
• purine nucleotides degradation II (aerobic) (9/11 steps found)
• ureide biosynthesis (6/7 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation I (plants) (8/12 steps found)
• adenosine nucleotides degradation I (5/8 steps found)
• superpathway of purines degradation in plants (11/18 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Drug metabolism - other enzymes
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.205

Protein Sequence (488 amino acids)

>EX28DRAFT_0139 inosine-5'-monophosphate dehydrogenase (Enterobacter asburiae PDN3)
MLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIA
LAQEGGIGFIHKNMSIERQAEEVRRVKKHESGIVSDPQTVLPTTTLHEVKALTERNGFAG
YPVVTEENELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREGETRDVVLAKMHEKRV
EKALVVDSSFHLRGMITVKDFQKAERKPNACKDEHGRLRVGAAVGAGAGNEERVDALVAA
GVDVLLIDSSHGHSEGVLQRIRDTRAKYPDLQIIGGNVATGAGARALADAGCSAVKVGIG
PGSICTTRIVTGVGVPQITAVSDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGAAAVMV
GSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQTDNAADKLVPEGIEGR
VAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDLLRTKAEFVRISGAGIQESHVHDVTITKE
SPNYRLGS