Protein Info for EFB2_02745 in Escherichia fergusonii Becca

Annotation: Fatty acid metabolism regulator protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 239 TIGR02812: fatty acid metabolism transcriptional regulator FadR" amino acids 2 to 235 (234 residues), 409.4 bits, see alignment E=2.3e-127 PF00392: GntR" amino acids 11 to 71 (61 residues), 70.6 bits, see alignment E=1e-23 PF07840: FadR_C" amino acids 72 to 234 (163 residues), 251.7 bits, see alignment E=4.5e-79 PF07729: FCD" amino acids 102 to 214 (113 residues), 26.1 bits, see alignment E=1.5e-09

Best Hits

Swiss-Prot: 100% identical to FADR_ECOBW: Fatty acid metabolism regulator protein (fadR) from Escherichia coli (strain K12 / MC4100 / BW2952)

KEGG orthology group: K03603, GntR family transcriptional regulator, negative regulator for fad regulon and positive regulator of fabA (inferred from 100% identity to eco:b1187)

Predicted SEED Role

"Transcriptional regulator for fatty acid degradation FadR, GntR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (239 amino acids)

>EFB2_02745 Fatty acid metabolism regulator protein (Escherichia fergusonii Becca)
MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGW
LTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAFRQH
PDKAQEVLATANEVADHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYF
ANPEARSLALGFYHKLSALCSEGAHDQVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR