Protein Info for EFB2_00294 in Escherichia fergusonii Becca

Annotation: Multidrug resistance protein MdtF

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1037 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 389 (24 residues), see Phobius details amino acids 395 to 416 (22 residues), see Phobius details amino acids 441 to 460 (20 residues), see Phobius details amino acids 471 to 497 (27 residues), see Phobius details amino acids 539 to 556 (18 residues), see Phobius details amino acids 872 to 890 (19 residues), see Phobius details amino acids 897 to 915 (19 residues), see Phobius details amino acids 925 to 948 (24 residues), see Phobius details amino acids 972 to 992 (21 residues), see Phobius details amino acids 1006 to 1030 (25 residues), see Phobius details PF00873: ACR_tran" amino acids 1 to 1027 (1027 residues), 1410.6 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1033 (1033 residues), 1702.9 bits, see alignment E=0 PF03176: MMPL" amino acids 338 to 499 (162 residues), 28.4 bits, see alignment E=1.2e-10

Best Hits

Swiss-Prot: 100% identical to MDTF_ECOL6: Multidrug resistance protein MdtF (mdtF) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 63% identity to abo:ABO_0964)

MetaCyc: 70% identical to multidrug efflux pump RND permease AcrF (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-367

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1037 amino acids)

>EFB2_00294 Multidrug resistance protein MdtF (Escherichia fergusonii Becca)
MANYFIDRPVFAWVLAIIMMLAGGLAIMNLPVAQYPQIAPPTITISATYPGADAQTVEDS
VTQVIEQNMNGLDGLMYMSSTSDAAGNASITLTFETGTSPDIAQVQVQNKLQLAMPSLPE
AVQQQGISVDKSSSNILMVAAFISDNGSLNQYDIADYVASNIKDPLSRTAGVGSVQLFGS
EYAMRIWLDPQKLNKYNLVPSDVISQIKVQNNQISGGQLGGMPQAADQQLNASIIVQTRL
QTPEEFGKILLKVQQDGSQVLLRDVARVELGAEDYSTVARYNGKPAAGIAIKLATGANAL
DTSRAVKEELNRLSAYFPASLKTVYPYDTTPFIKISIQEVFKTLVEAIILVFLVMYLFLQ
NFRATIIPTIAVPVVILGTFAILSAVGFTINTLTMFGMVLAIGLLVDDAIVVVENVERVI
AEDKLPPKEATHKSMGQIQRALVGIAVVLSAVFMPMAFMSGATGEIYRQFSITLISSMLL
SVFVAMSLTPALCATILKAAPEGDHKPNALFARFNTLFEKSTQHYTDSTRSLLRCTGRYM
VVYLLICAGMAVLFLRTPTSFLPEEDQGVFMTTAQLPSGATMVNTTKVLQQVTDYYLTKE
KNNVQSVFTVGGFGFSGQGQNNGLAFISLKPWSERVGEENSVTAIIQRAMIALSSINKAV
VFPFNLPAVAELGTASGFDMELLDNGNLGHEKLTQARNELLSLAAQSPNQVIGVRPNGLE
DTPMFKVNVNAAKAEAMGVALSDINQTISTAFGSSYVNDFLNQGRVKKVYVQAGTPFRML
PDNINQWYVRNASGTMAPLSAYSSTEWTYGSPRLERYNGIPSMEILGEAAAGKSTGDAMK
FMADLVAKLPAGVGYSWTGLSYQEALSSNQAPALYAISLVVVFLALAALYESWSIPFSVM
LVVPLGVVGALLATDLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAVEMMQKEGKTPVE
AIIEAARMRLRPILMTSLAFILGVLPLVISHGAGSGAQNAVGTGVMGGMFAATVLAIYFV
PVFFVVVEHLFARFKKA