Protein Info for ECD_03762 in Escherichia coli BL21

Annotation: putative 2,3-dihydroxypropane-1-sulfonate exporter, membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 468 transmembrane" amino acids 28 to 48 (21 residues), see Phobius details amino acids 60 to 79 (20 residues), see Phobius details amino acids 99 to 117 (19 residues), see Phobius details amino acids 128 to 150 (23 residues), see Phobius details amino acids 170 to 190 (21 residues), see Phobius details amino acids 196 to 217 (22 residues), see Phobius details amino acids 251 to 272 (22 residues), see Phobius details amino acids 285 to 304 (20 residues), see Phobius details amino acids 316 to 334 (19 residues), see Phobius details amino acids 340 to 363 (24 residues), see Phobius details amino acids 395 to 411 (17 residues), see Phobius details amino acids 427 to 449 (23 residues), see Phobius details TIGR00792: sugar (Glycoside-Pentoside-Hexuronide) transporter" amino acids 26 to 464 (439 residues), 532.6 bits, see alignment E=3.3e-164 PF13347: MFS_2" amino acids 28 to 451 (424 residues), 261.6 bits, see alignment E=1e-81 PF07690: MFS_1" amino acids 109 to 396 (288 residues), 37.7 bits, see alignment E=1.2e-13

Best Hits

Swiss-Prot: 100% identical to YIHP_ECOLI: Putative 2,3-dihydroxypropane-1-sulfonate exporter (yihP) from Escherichia coli (strain K12)

KEGG orthology group: K03292, glycoside/pentoside/hexuronide:cation symporter, GPH family (inferred from 100% identity to ecj:JW3848)

MetaCyc: 65% identical to putative sulfoquinovose transporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-580

Predicted SEED Role

"Glucuronide transport protein YihP, homologous to YihO"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (468 amino acids)

>ECD_03762 putative 2,3-dihydroxypropane-1-sulfonate exporter, membrane protein (Escherichia coli BL21)
MGKGRTSMSHITTEDPATLRLPFKEKLSYGIGDLASNILLDIGTLYLLKFYTDVLGLPGT
YGGIIFLISKFFTAFTDMGTGIMLDSRRKIGPKGKLRPFILYASFPVTLLAIANFVGTPF
DVTGKTVMATILFMLYGLFFSMMNCSYGAMVPAITKNPNERASLAAWRQGGATLGLLLCT
VGFVPVMNLIEGNQQLGYIFAATLFSLFGLLFMWICYSGVKERYVETQPANPAQKPGLLQ
SFRAIAGNRPLFILCIANLCTLGAFNVKLAIQVYYTQYVLNDPILLSYMGFFSMGCIFIG
VFLMPASVRRFGKKKVYIGGLLIWVLGDLLNYFFGGGSVSFVAFSCLAFFGSAFVNSLNW
ALVSDTVEYGEWRTGVRSEGTVYTGFTFFRKVSQALAGFFPGWMLTQIGYVPNVAQADHT
IEGLRQLIFIYPSALAVVTIVAMGCFYSLNEKMYVRIVEEIEARKRTA