Protein Info for ECD_01701 in Escherichia coli BL21

Annotation: catalase HPII, heme d-containing

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 753 PF00199: Catalase" amino acids 81 to 466 (386 residues), 596.1 bits, see alignment E=4.8e-183 PF06628: Catalase-rel" amino acids 499 to 562 (64 residues), 67.4 bits, see alignment E=1.5e-22 PF18011: Catalase_C" amino acids 599 to 746 (148 residues), 51.8 bits, see alignment E=1.1e-17

Best Hits

Swiss-Prot: 100% identical to CATE_ECOLI: Catalase HPII (katE) from Escherichia coli (strain K12)

KEGG orthology group: K03781, catalase [EC: 1.11.1.6] (inferred from 100% identity to eco:b1732)

MetaCyc: 100% identical to catalase HPII (Escherichia coli K-12 substr. MG1655)
Catalase. [EC: 1.11.1.21, 1.11.1.6]; RXN-8073 [EC: 1.11.1.21, 1.11.1.6]

Predicted SEED Role

"Catalase (EC 1.11.1.6)" in subsystem Oxidative stress or Photorespiration (oxidative C2 cycle) (EC 1.11.1.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.6

Use Curated BLAST to search for 1.11.1.21 or 1.11.1.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (753 amino acids)

>ECD_01701 catalase HPII, heme d-containing (Escherichia coli BL21)
MSQHNEKNPHQHQSPLHDSSEAKPGMDSLAPEDGSHRPAAEPTPPGAQPTAPGSLKAPDT
RNEKLNSLEDVRKGSENYALTTNQGVRIADDQNSLRAGNRGPTLLEDFILREKITHFDHE
RIPERIVHARGSAAHGYFQPYKSLSDITKADFLSDPNKITPVFVRFSTVQGGAGSADTVR
DIRGFATKFYTEEGIFDLVGNNTPIFFIQDAHKFPDFVHAVKPEPHWAIPQGQSAHDTFW
DYVSLQPETLHNVMWAMSDRGIPRSYRTMEGFGIHTFRLINAEGKATFVRFHWKPLAGKA
SLVWDEAQKLTGRDPDFHRRELWEAIEAGDFPEYELGFQLIPEEDEFKFDFDLLDPTKLI
PEELVPVQRVGNMVLNRNPDNFFAENEQAAFHPGHIVPGLDFTNDPLLQGRLFSYTDTQI
SRLGGPNFHEIPINRPTCPYHNFQRDGMHRMGIDTNPANYEPNSINDNWPRETPPGPKRG
GFESYQERVEGNKVRERSPSFGEYYSHPRLFWLSQTPFEQRHIVDGFSFELSKVVRPYIR
ERVVDQLAHIDLTLAQAVAKNLGIELTDDQLNITPPPDVNGLKKDPSLSLYAIPDGDVKG
RVVAILLNDEVRSADLLAILKALKAKGVHAKLLYSRMGEVTADDGTVLPIAATFAGAPSL
TVDAVIVPCGNIADIADNGDANYYLMEAYKHLKPIALAGDARKFKATIKVADQGEEGIVE
ADSADGSFMDELLTLMAAHRVWSRIPKIDKIPA