Protein Info for DZA65_RS19080 in Dickeya dianthicola ME23

Annotation: preprotein translocase subunit SecA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 897 PF07517: SecA_DEAD" amino acids 7 to 401 (395 residues), 433.4 bits, see alignment E=1e-133 TIGR00963: preprotein translocase, SecA subunit" amino acids 28 to 816 (789 residues), 1152.7 bits, see alignment E=0 PF01043: SecA_PP_bind" amino acids 232 to 358 (127 residues), 140 bits, see alignment E=1.1e-44 PF21090: P-loop_SecA" amino acids 417 to 615 (199 residues), 313.6 bits, see alignment E=1.5e-97 PF07516: SecA_SW" amino acids 617 to 830 (214 residues), 245.1 bits, see alignment E=1.8e-76 PF02810: SEC-C" amino acids 876 to 894 (19 residues), 40.7 bits, see alignment (E = 4.3e-14)

Best Hits

Swiss-Prot: 73% identical to SECA_AERHH: Protein translocase subunit SecA (secA) from Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)

KEGG orthology group: K03070, preprotein translocase subunit SecA (inferred from 73% identity to aha:AHA_3877)

Predicted SEED Role

"Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1)" (TC 3.A.5.1.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CL02 at UniProt or InterPro

Protein Sequence (897 amino acids)

>DZA65_RS19080 preprotein translocase subunit SecA (Dickeya dianthicola ME23)
MLIKLLTKVFGSRNDRALRRMRKIVDVINRFEPDMEKLSDDELKAKTQVFRDRIKKGETL
ESLLPEAFAVVREASKRVFGMRHFDVQLIGGMVLNERCIAEMRTGEGKTLTATLPAYLNA
LTGRGVHVVTVNDYLAQRDAENNRPLFEFLGLSVGINLPGMPAPAKRDAYAADITYGTNN
EYGFDYLRDNMAFSPEERVQRELYYALVDEVDSILIDEARTPLIISGPAEDSSELYMRVN
KIIPHLIRQEKEDSDTFHGEGHFSVDEKARQVNLTERGLVKIEELLVQGGIMNEGESLYS
PANIMLMHHVTAALRAHVLFTRDVDYIVKDDEVIIVDEHTGRTMQGRRWSDGLHQAVEAK
ENVKINNENQTLASITFQNYFRIYEKLAGMTGTADTEAFEFSSIYKLDTIVVPTNRPMVR
KDLPDLVYMTEQEKINAIIEDIRDRTAKGQPVLVGTISIEKSEVVSDALTKAGVKHNVLN
AKFHAMEADIVAQAGRSGAVTIATNMAGRGTDIVLGGSWQAEVAQQENPDEGQIAAIKAE
WQQRHDDVLAAGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSMEDALMRIFAS
DRVSNMMRKLGMKEGEAIEHPWVTKAIANAQRKVENRNFDIRKQLLEYDDVANDQRRAIY
TQRNELLDVSDISETINSIREDVFKVTIDAHIPPQSLEEMWDIPGLEQRLKNDFDLELPI
AQWLDKEPELHEETLRERIYEQALEVYSRKEEVVGSDVMRNFEKGVMLQTLDSLWKEHLA
AMDYLRQGIHLRGYAQKDPKQEYKRESFAMFAAMLEGLKYEVISTLSKVQVRMPEEIEAL
ELQRREEAERLARQQQLSHQDESATGSPYADRKVGRNDPCPCGSGKKYKQCHGRLQK