Protein Info for DZA65_RS19030 in Dickeya dianthicola ME23

Annotation: nucleoside-specific channel-forming protein Tsx

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 287 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF03502: Channel_Tsx" amino acids 30 to 287 (258 residues), 278.1 bits, see alignment E=4e-87

Best Hits

Swiss-Prot: 73% identical to TSX_SHIFL: Nucleoside-specific channel-forming protein Tsx (tsx) from Shigella flexneri

KEGG orthology group: K05517, nucleoside-specific channel-forming protein (inferred from 96% identity to ddc:Dd586_3513)

MetaCyc: 73% identical to nucleoside-specific channel-forming protein Tsx (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-468

Predicted SEED Role

"Nucleoside-specific channel-forming protein Tsx precursor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4C6I5 at UniProt or InterPro

Protein Sequence (287 amino acids)

>DZA65_RS19030 nucleoside-specific channel-forming protein Tsx (Dickeya dianthicola ME23)
MKKILAACAISTLSYSLPTLADGNSPQYLSDWWHQSINVVGSYHTRFGPQLNNDLYLEYE
AFAHKDWFDFYGYIDVPRVFGAGNTPDRGIWNKGSPLFMEIEPRFSINKLTNTQLGFGPF
KEWYVANNIIYDQGRNNDSRQSTWYVGLGTDINTGTDLSLSANIYAKYQWQNYSALNEDR
WDGYRFKIKYFYPITSLWGGKLTYIGFTNFDFGSDLANAAGPSRTSNAIASSHILALNYD
HWHYSVVARYFHNGGQWADGTELDFGRGPFNARSTGWGYYLVAGYNF