Protein Info for DZA65_RS16770 in Dickeya dianthicola ME23

Annotation: 3-phenylpropionate MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 382 transmembrane" amino acids 7 to 28 (22 residues), see Phobius details amino acids 40 to 60 (21 residues), see Phobius details amino acids 71 to 89 (19 residues), see Phobius details amino acids 94 to 114 (21 residues), see Phobius details amino acids 133 to 152 (20 residues), see Phobius details amino acids 158 to 177 (20 residues), see Phobius details amino acids 206 to 229 (24 residues), see Phobius details amino acids 237 to 258 (22 residues), see Phobius details amino acids 270 to 288 (19 residues), see Phobius details amino acids 294 to 317 (24 residues), see Phobius details amino acids 330 to 352 (23 residues), see Phobius details amino acids 358 to 375 (18 residues), see Phobius details PF03825: Nuc_H_symport" amino acids 2 to 325 (324 residues), 29.8 bits, see alignment E=6.4e-11 PF12832: MFS_1_like" amino acids 8 to 361 (354 residues), 193.8 bits, see alignment E=1e-60 PF07690: MFS_1" amino acids 9 to 313 (305 residues), 54 bits, see alignment E=2.6e-18

Best Hits

Swiss-Prot: 66% identical to HCAT_ECOLI: Probable 3-phenylpropionic acid transporter (hcaT) from Escherichia coli (strain K12)

KEGG orthology group: K05820, MFS transporter, PPP family, 3-phenylpropionic acid transporter (inferred from 94% identity to ddd:Dda3937_02383)

Predicted SEED Role

"Probable 3-phenylpropionic acid transporter" in subsystem Cinnamic Acid Degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385Y2M5 at UniProt or InterPro

Protein Sequence (382 amino acids)

>DZA65_RS16770 3-phenylpropionate MFS transporter (Dickeya dianthicola ME23)
MVLQSTYWLALGYFTYFFSYGIFLPFWGGWLKGEGLPAEAIGILLGIGLVARFAGSLFIT
PLVKDPARLITVLRLLALLSLLTSIGFWLGSAWLWLMLVMIGFNLFFAPLIPLTDALAAT
WQKQITLDYGRVRVWGSVAFVIGSAVTGQLVVVWGHQAILAILAAGLLSMLLGMALQPHV
MPASVKRHQTQTAATPWRVLLREPAVWRFLLSVSLLQGAHAAYYGFSVIYWQQAGYSAAV
IGYLWSLGVVAEIVIFALSKRLFRHWSASGLLMLSALCGVVRWSLMVATVSPPWLIVIQI
LHCGTFTVCHLAAMRFISSRNDADVLRLQAAYSALGTGGAVAVMTVVSGFLFEYLQGGTF
WVMALLVLPAFVLRPQVSTRSR