Protein Info for DZA65_RS11665 in Dickeya dianthicola ME23

Annotation: PTS mannose/fructose/sorbose transporter subunit IIC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 87% identical to PTNC_SHIFL: PTS system mannose-specific EIIC component (manY) from Shigella flexneri

KEGG orthology group: K02795, PTS system, mannose-specific IIC component (inferred from 98% identity to ddd:Dda3937_03726)

MetaCyc: 87% identical to mannose-specific PTS enzyme IIC component (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-157 [EC: 2.7.1.199]; 2.7.1.199 [EC: 2.7.1.199]; TRANS-RXN-167 [EC: 2.7.1.199, 2.7.1.193]; TRANS-RXN-165 [EC: 2.7.1.199, 2.7.1.193, 2.7.1.191]; 2.7.1.191 [EC: 2.7.1.199, 2.7.1.193, 2.7.1.191]

Predicted SEED Role

"PTS system, mannose-specific IIC component"

MetaCyc Pathways

superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (25/26 steps found)
superpathway of glycolysis and the Entner-Doudoroff pathway (16/17 steps found)
glycolysis I (from glucose 6-phosphate) (13/13 steps found)
D-mannose degradation I (2/2 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.191 or 2.7.1.193 or 2.7.1.199

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385XXX2 at UniProt or InterPro

Protein Sequence (265 amino acids)

>DZA65_RS11665 PTS mannose/fructose/sorbose transporter subunit IIC (Dickeya dianthicola ME23)
MEITTLQIVLIFIVACISGMGSILDEFQFHRPLVACTLIGLVLGDLKTGIIIGGTLEMIA
LGWMNIGAAVAPDAALASIISTILVIAGGQSVGAGIALAIPLAAAGQVLTIIVRTITVAF
QHAADSAAERGNLSAISWIHISALLLQAMRIAIPAVIVAISVGTEAVHGLLASIPDVVTT
GLNIAGGMIVVVGYAMVINMMRAGYLMPFFYLGFVTAAFTNFNLVALGVIGVVMAVLYIQ
LSPKYNKSQGVAAASSNNDLDNELD