Protein Info for DZA65_RS11215 in Dickeya dianthicola ME23

Annotation: potassium transporter Kup

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 622 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 49 to 70 (22 residues), see Phobius details amino acids 100 to 123 (24 residues), see Phobius details amino acids 139 to 159 (21 residues), see Phobius details amino acids 167 to 188 (22 residues), see Phobius details amino acids 208 to 231 (24 residues), see Phobius details amino acids 244 to 266 (23 residues), see Phobius details amino acids 286 to 311 (26 residues), see Phobius details amino acids 336 to 357 (22 residues), see Phobius details amino acids 363 to 383 (21 residues), see Phobius details amino acids 395 to 416 (22 residues), see Phobius details amino acids 422 to 439 (18 residues), see Phobius details PF02705: K_trans" amino acids 13 to 462 (450 residues), 578.7 bits, see alignment E=6.7e-178 PF22776: K_trans_C" amino acids 473 to 622 (150 residues), 135.9 bits, see alignment E=1e-43

Best Hits

Swiss-Prot: 53% identical to KUP1_BRASO: Probable potassium transport system protein kup 1 (kup1) from Bradyrhizobium sp. (strain ORS 278)

KEGG orthology group: K03549, KUP system potassium uptake protein (inferred from 96% identity to ddd:Dda3937_03862)

MetaCyc: 44% identical to K+:H+ symporter Kup (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-3

Predicted SEED Role

"Kup system potassium uptake protein" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CYL5 at UniProt or InterPro

Protein Sequence (622 amino acids)

>DZA65_RS11215 potassium transporter Kup (Dickeya dianthicola ME23)
MTHTQQEKTPGLLAISALGIVFGDIGTSPLYTFNTVIQLAGDAAQPETILGLLSTLFWTL
IIVTSIKYALFAMRIDNKGEGGVLALMSLLQNNQAKRQKWIIAAGLLGAAFIYGDGAITP
AISVLSALEGLELVLPETANYILPLTLVLLILIFAIQPLGTAKISQFFAPVMLLWFATLA
LLGIKSIMDYPAVLWALNPVHALTFFATHGHIGLLILGGVFLCVTGAEALYADMGHFGRK
PIWIAWYAIALPCLLLNYAGQAAFILSGTDANNNILYRLCPPALQIPLVILATLSTIIAS
QAIISGAFSMTRQAIQLGWLPRMKITQTAEQSYGQIYLGTVNWLLMAVTLSLVIFFQSSE
RLAAAYGIAVSITMLMTTLLLYMAMRKIWHWNKMLSLSITAIFILIDVGFCVANMLKVFD
GGYVPLLLAMLIFCVMFIWRRGVTRVSQTVAEETLPVDKFLSSLQADGISRVPGVAVFLT
RVQNVAPPVMRWHVKRNQALHDKIIALTIQVLDVPRVREEDKLVMTEKLPGFWQGVAYYG
FMEKPNIPELLRQTPPLKACVDHESVTYYIGHESIVAKDSADALPRWQSYLFGWMMRNCL
HVTEYYQLPGNQVIEIGRRIAI