Protein Info for DZA65_RS09905 in Dickeya dianthicola ME23

Annotation: cysteine/glutathione ABC transporter permease/ATP-binding protein CydD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 588 transmembrane" amino acids 24 to 53 (30 residues), see Phobius details amino acids 62 to 79 (18 residues), see Phobius details amino acids 143 to 161 (19 residues), see Phobius details amino acids 167 to 188 (22 residues), see Phobius details amino acids 245 to 270 (26 residues), see Phobius details amino acids 278 to 297 (20 residues), see Phobius details TIGR02857: thiol reductant ABC exporter, CydD subunit" amino acids 21 to 556 (536 residues), 644.2 bits, see alignment E=9.9e-198 PF00664: ABC_membrane" amino acids 26 to 292 (267 residues), 151 bits, see alignment E=8.7e-48 PF00005: ABC_tran" amino acids 369 to 513 (145 residues), 103.9 bits, see alignment E=1.7e-33

Best Hits

Swiss-Prot: 70% identical to CYDD_ECOLI: ATP-binding/permease protein CydD (cydD) from Escherichia coli (strain K12)

KEGG orthology group: K06148, ATP-binding cassette, subfamily C, bacterial (inferred from 96% identity to ddd:Dda3937_03630)

MetaCyc: 70% identical to glutathione/L-cysteine ABC exporter subunit CydD (Escherichia coli K-12 substr. MG1655)
7.4.2.-; 3.6.3.M9 [EC: 3.6.3.M9]

Predicted SEED Role

"Transport ATP-binding protein CydD" in subsystem Terminal cytochrome d ubiquinol oxidases or Terminal cytochrome oxidases

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.3.M9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4D5I3 at UniProt or InterPro

Protein Sequence (588 amino acids)

>DZA65_RS09905 cysteine/glutathione ABC transporter permease/ATP-binding protein CydD (Dickeya dianthicola ME23)
MKDTRQQELTRWLKQQSRLAHRWLRLSLMLGLASGLLIMAQAWLLASLLHALIIAHTPRN
ELITTFWLLAMTFVLRALTNWIRERVGFRCGQTIRQHIRQQVLDRLQQLGPAWIQGKPAG
SWATLILEQVDDMHDYYARYLPQMYLAVLIPVLILIIVFPVNWAAGVILLATAPLIPLFM
AMVGMGAADANHRNFQALARLSGNFLDRLRGLDTLRLFYRGEAETEQIRQASEQFRSRTM
EVLRMAFLSSGVLEFFASISIAVVAVYFGFSYLGELHFGSYGVGVTLFAGFLVLILAPEF
FQPLRDLGTFYHAKAQAVGAAEALHRFMTAESAETGAGTRLFQSDTPVTLRAHELTILSP
SGKTLAGPLTFTLDAGQRVALVGPSGAGKSSLLNLLLGFLPYRGSLTVNGEELRTLSSTS
WRQHLSWVGQNPHLPEPTLRQNVLLGRPEASDHTLQQALERAYVHEFLPQLPLGLDTPLG
DGAARLSVGQAQRVAVARALLHPCRLLLLDEPSASLDAHSEQRVMSALSEASHAQTTLLV
THQLSEIRDYDEIWVMVNGQLVQQGDYLTLSQASGPFADLLAQRRGEL