Protein Info for DZA65_RS08975 in Dickeya dianthicola ME23
Annotation: malonyl-ACP O-methyltransferase BioC
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 60% identical to BIOC_PECAS: Malonyl-[acyl-carrier protein] O-methyltransferase (bioC) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
KEGG orthology group: K02169, biotin synthesis protein BioC (inferred from 92% identity to ddd:Dda3937_03750)MetaCyc: 48% identical to malonyl-acyl carrier protein methyltransferase (Escherichia coli K-12 substr. MG1655)
RXN-11475 [EC: 2.1.1.197]
Predicted SEED Role
"SAM-dependent methyltransferase, BioC-like"
MetaCyc Pathways
- biotin biosynthesis I (15/15 steps found)
- 8-amino-7-oxononanoate biosynthesis I (11/11 steps found)
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.1.1.197
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A385XYJ1 at UniProt or InterPro
Protein Sequence (260 amino acids)
>DZA65_RS08975 malonyl-ACP O-methyltransferase BioC (Dickeya dianthicola ME23) MTLVNASSLSHPPHKQAIAHAFGRAAGDYDRFAALQRESGEQLMALVGDHAGSELLDAGC GTGYFSARWQASGKQVTALDLSTEMLAIARQRRAATHYLQGDIEHLPLADGSVDISFSNM AMQWCDDFDAGLAELYRVTRPGGAIAICTLAQGTLAELDAAWQQLDGSRRINRFLSLEAV VSACRRYHADVSLAPVTCYFPDVLSLMRSVKGVGATWLRDGREHGGLSRRHLTALTAHYD CHPQGYPLTYQRVFGVIYRD