Protein Info for DZA65_RS07475 in Dickeya dianthicola ME23

Annotation: phosphonopyruvate decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02776: TPP_enzyme_N
  • amino acids 6 to 105 (100 residues), 37.6 bits, E=1.7e-13
• TIGR03297: phosphonopyruvate decarboxylase
  • amino acids 15 to 362 (348 residues), 390.6 bits, E=3.3e-121
• PF02775: TPP_enzyme_C
  • amino acids 220 to 336 (117 residues), 62.6 bits, E=3.9e-21

Predicted SEED Role

"Phosphonopyruvate decarboxylase (EC 4.1.1.82)" (EC 4.1.1.82)

MetaCyc Pathways

• 2-aminoethylphosphonate biosynthesis (3/3 steps found)
• methylphosphonate biosynthesis (2/4 steps found)
• fosfomycin biosynthesis (2/7 steps found)
• dehydrophos biosynthesis (3/13 steps found)
• rhizocticin A and B biosynthesis (2/12 steps found)
• phosalacine biosynthesis (4/25 steps found)
• phosphinothricin tripeptide biosynthesis (4/25 steps found)

KEGG Metabolic Maps

• Aminophosphonate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.82

Sequence Analysis Tools

See A0A3A4CD72 at UniProt or InterPro

Protein Sequence (372 amino acids)

>DZA65_RS07475 phosphonopyruvate decarboxylase (Dickeya dianthicola ME23)
MENALHFTRQLKQAGFNFFSGVPCSFLTQVINQAIADPELDYVPATSEGEAVALAAGAWL
AGKQAVVMCQNSGLGNMVNPLTSLNAAFDIPVLLVVTHRGKPGIKDEPQHRLMGKITPEL
LALLGIPATVLPADATAMREVIAHAMHLVRDEQKTAALIVEKGIFSEATPVVKETGGLPE
RATVLELLLNLAGERDFLIATTGKTGRELFTLKDRVNNLYCVGSMGYASALAQGIALYAP
QRTVTIIDGDGSALMHPGNMATIGHLRSSNLIHLLLNNGAYDSTGGQKTLADGVDFSLVA
RGMGYTHAQYCSTLTELADAYRYAQMHDHGPVLLIVNIANGSMGELGRPTITPEQIARRL
QHQIKESFFHDC