Protein Info for DZA65_RS07095 in Dickeya dianthicola ME23

Annotation: tyrosine-protein kinase Wzc

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 726 transmembrane" amino acids 32 to 51 (20 residues), see Phobius details amino acids 425 to 446 (22 residues), see Phobius details PF02706: Wzz" amino acids 16 to 107 (92 residues), 76.5 bits, see alignment E=5.7e-25 PF23607: WZC_N" amino acids 112 to 204 (93 residues), 75.5 bits, see alignment E=1.5e-24 PF13807: GNVR" amino acids 367 to 447 (81 residues), 112.2 bits, see alignment E=3.2e-36 TIGR01007: capsular exopolysaccharide family" amino acids 509 to 710 (202 residues), 160 bits, see alignment E=2.8e-51 PF10609: ParA" amino acids 528 to 697 (170 residues), 32.7 bits, see alignment E=1.8e-11 PF13614: AAA_31" amino acids 531 to 653 (123 residues), 41.5 bits, see alignment E=4.9e-14 PF01656: CbiA" amino acids 531 to 661 (131 residues), 28.1 bits, see alignment E=6.3e-10 PF00142: Fer4_NifH" amino acids 538 to 594 (57 residues), 26.6 bits, see alignment 1.5e-09

Best Hits

Swiss-Prot: 56% identical to WZC_SALTY: Tyrosine-protein kinase wzc (wzc) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: None (inferred from 92% identity to ddd:Dda3937_03927)

MetaCyc: 56% identical to protein-tyrosine kinase Wzc (Escherichia coli K-12 substr. MG1655)
Receptor protein-tyrosine kinase. [EC: 2.7.10.1, 2.7.10.2, 2.7.10.3, 2.7.12.1]

Predicted SEED Role

"Tyrosine-protein kinase Wzc (EC 2.7.10.2)" in subsystem Colanic acid biosynthesis (EC 2.7.10.2)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.10.1 or 2.7.10.2 or 2.7.10.3 or 2.7.12.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385XYN7 at UniProt or InterPro

Protein Sequence (726 amino acids)

>DZA65_RS07095 tyrosine-protein kinase Wzc (Dickeya dianthicola ME23)
MSEKIAVKTSEANKADEIDLGRLLGTVLDHCWLIISIITIFTMLGILYTLLATPIYQSDA
LVQVEQNSSDNLLKDISSVLPDAKPDSSAEIELIQSRMVIGKTVQDLSLDTEVKEKFFPV
VGKGLARLLGRTPGQILVSRLSVPALQRDEPMKLEVLGNGAYRLERKDEGTFEGKVGQLA
SHDGVELLVSDIDAVPGTVFVVTKKNELSAINDVLNNLTVADKGKDTGILDLTLSGEDPV
LINKILNSISHNYLEQNVERKSEEAGKSLVFLQQQLPVVRASLEDSENKLNKFRQQNDSV
DLSLEAKSVLDTIVDVESQLNQLTFREAEISKLYTREHPAYRALLEKRVTLEKERNSLNK
RVGSMPKTQQEILRLTRDVNVGQEVYVQLMNKQQELSISKASTVGNVRIIDPAEVQIKPV
KPKRVLVILLSVVLGGVIAVSFVLLKTLLHHGIESPEQLEELGINVYASVPLSEWQQKKD
REFTGKNRKQNARSHSLLAVGNPADLAIEAIRSLRTSLHFAMMEAKNNVLMISGASPGIG
KSFISANLGAVIAQAGQRVLIVDCDMRKGYAHHMLGTTADKGLSDILSGQVEAEKATRST
AVTNMFFIPRGQIPPNPSELLMHKNFVAFVEWAAQSFDIVLLDTPPILAVTDAAIISRQA
GTSLLVARFETNTPKEVEISIRRFEQNGASIKGVILNAVIRRALSYYSYGYDSYQYSYDS
DKKNSV