Protein Info for DZA65_RS06130 in Dickeya dianthicola ME23

Annotation: mechanosensitive channel MscK

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1126 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 509 to 529 (21 residues), see Phobius details amino acids 559 to 580 (22 residues), see Phobius details amino acids 592 to 613 (22 residues), see Phobius details amino acids 637 to 653 (17 residues), see Phobius details amino acids 665 to 686 (22 residues), see Phobius details amino acids 698 to 723 (26 residues), see Phobius details amino acids 736 to 756 (21 residues), see Phobius details amino acids 801 to 824 (24 residues), see Phobius details amino acids 847 to 867 (21 residues), see Phobius details amino acids 888 to 909 (22 residues), see Phobius details amino acids 921 to 948 (28 residues), see Phobius details PF12795: MscS_porin" amino acids 60 to 295 (236 residues), 205.9 bits, see alignment E=1.8e-64 PF12794: MscS_TM" amino acids 515 to 833 (319 residues), 320.4 bits, see alignment E=3e-99 PF21088: MS_channel_1st" amino acids 894 to 935 (42 residues), 38 bits, see alignment (E = 3.2e-13) PF00924: MS_channel_2nd" amino acids 937 to 1002 (66 residues), 86.1 bits, see alignment 3.7e-28 PF21082: MS_channel_3rd" amino acids 1011 to 1093 (83 residues), 66.6 bits, see alignment 5.4e-22

Best Hits

Swiss-Prot: 63% identical to MSCK_ECOLI: Mechanosensitive channel MscK (mscK) from Escherichia coli (strain K12)

KEGG orthology group: K05802, potassium efflux system protein KefA (inferred from 96% identity to ddd:Dda3937_03297)

MetaCyc: 63% identical to potassium dependent, small conductance mechanosensitive channel (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-86

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CVX3 at UniProt or InterPro

Protein Sequence (1126 amino acids)

>DZA65_RS06130 mechanosensitive channel MscK (Dickeya dianthicola ME23)
MSRCFAISGSFAVLFRSFLDDSVRRSLPYLWAFLLGAMPLWPALAAGSDLPTRTEIQNRL
DTLNKQKSLTSVDKLTQQDLTQTLDVLDAIDRVRQETSQLKQQAAQAPTKLKQVNEDLVS
LGGAAPVSQPSLESLSLKQLEARLNETLDDLQSAQENLSTYNSQLISLQTQPERVQSALY
AASQRSQQLRTQLSGLDPSQEPLRPSQQVLLQAEQALVGLQMEQQRKSLEVNTTMQDLLQ
KQRDYTAAQIGQLEHMVQTLQGVINNKRLNLSEKTAKEAQNSDELQRIQENPLVKTEMET
NRQLSQRLIKATEAGNTLVQESIQVKNWLDRATQSERNLKEQITVLKGSLLLSRILYQQQ
QNLPSADSMGNISTQIADLRLEQFDINQQRDVLFRGDEYIQQLVVHSNATVDTEVTDALE
QILDMRRELLDQLNKQLGNQLMLAINLQISRQQLMSVNDSLQRTLTQQIFWVSSNKPMDW
SWLKDLPSTLKQQVKNLRFNLKGTQLGQGVMDSLLLIIPALLVVGLLLWRRKSIDAHMGK
LADDVGQLKRDSQLHTPKAILLLILRTLPGVLVVLSLGLWLKRTDSQISSFAWLLSKNLA
LFWMVFATAWFSLKPGSLSERHFNIPASRCAHYRRQTLRLGGALLPLMFWSVVGEKTPLY
LVDDAIGQIIIVCNLMLLTILVFPVCRDCWREKERHTVQLIVVTMMAAMPLFLIGLMLNG
FFYTTLRLASRWIDSLYLLIVWNIVYFATIRGLSVAARRLAYRRAVARRQNLVKEGAEGS
EPVPEAPLALEQISQQSLRLTTMVLFLAFSGAFYWIWADLVTVFSYLDSITLWHYSTTGA
SGTVLQPVTLGNLLVATVIGGVAYVMTRNLPGLLEVLVLSRLQLRQGASYAITTMLTYLI
TAVGAVTSLSSLGVSWDKLQWLVAALSVGLGFGLQEIFANFVSGLIILFERPVRIGDTIT
IGTFSGSVSKIRIRATTITDFDRKEVIIPNKAFVTERLINWSLSDTITRVLIRIGVAYGS
DLDKVKAVLLQAAHDNARVMTDPEPQVFFLSFGASALEHELRLYVRELRDRSYTVDELNR
TIDRLCRENNIDIAFNQLEVYLHNAQGEVQEVSRVLAQRQDVIETR