Protein Info for DZA65_RS05940 in Dickeya dianthicola ME23

Annotation: 2-dehydropantoate 2-reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 306 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details TIGR00745: 2-dehydropantoate 2-reductase" amino acids 2 to 294 (293 residues), 263.4 bits, see alignment E=1.4e-82 PF02558: ApbA" amino acids 3 to 143 (141 residues), 96.3 bits, see alignment E=1.4e-31 PF08546: ApbA_C" amino acids 172 to 292 (121 residues), 118.2 bits, see alignment E=3e-38

Best Hits

Swiss-Prot: 60% identical to PANE_ECOLI: 2-dehydropantoate 2-reductase (panE) from Escherichia coli (strain K12)

KEGG orthology group: K00077, 2-dehydropantoate 2-reductase [EC: 1.1.1.169] (inferred from 96% identity to ddd:Dda3937_01965)

MetaCyc: 60% identical to 2-dehydropantoate 2-reductase (Escherichia coli K-12 substr. MG1655)
2-dehydropantoate 2-reductase. [EC: 1.1.1.169]

Predicted SEED Role

"2-dehydropantoate 2-reductase (EC 1.1.1.169)" in subsystem Coenzyme A Biosynthesis (EC 1.1.1.169)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.169

Use Curated BLAST to search for 1.1.1.169

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CQW2 at UniProt or InterPro

Protein Sequence (306 amino acids)

>DZA65_RS05940 2-dehydropantoate 2-reductase (Dickeya dianthicola ME23)
MKITVLGCGAIGQLWLNALHRQGHDVQGWLRIPQVSCQVNVTMLSGERCNLNLAANNTEH
LAQSELLLVTLKAWQVSDTVSSLLPRLRPDCTILLLHNGMGTWEELPAISQPLLLGVTTH
AARRDPATVVHVAAGITHIGTLDRSTHREEEQSQLAETLHQALPDVAWHNHITATCWLKL
AANCVINPLTVLHQCTNGELQAYPEQVEALCQEVAQVMDREGFHTSSESLQLYVNQIIQN
TAANTSSMRQDVLAQRHTEIDYITGYLLRRARAHGLSLPENSRLFDYIKRKENEYDRLGS
GLSGAW