Protein Info for DZA65_RS04740 in Dickeya dianthicola ME23

Annotation: HsdR family type I site-specific deoxyribonuclease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1031 PF04313: HSDR_N" amino acids 6 to 202 (197 residues), 138.4 bits, see alignment E=5.8e-44 TIGR00348: type I site-specific deoxyribonuclease, HsdR family" amino acids 12 to 700 (689 residues), 549.9 bits, see alignment E=4.7e-169 PF04851: ResIII" amino acids 252 to 422 (171 residues), 64.2 bits, see alignment E=2.9e-21 PF18766: SWI2_SNF2" amino acids 255 to 486 (232 residues), 235.1 bits, see alignment E=1.5e-73 PF22679: T1R_D3-like" amino acids 530 to 685 (156 residues), 126.6 bits, see alignment E=2.5e-40

Best Hits

KEGG orthology group: K01153, type I restriction enzyme, R subunit [EC: 3.1.21.3] (inferred from 97% identity to kpe:KPK_4972)

Predicted SEED Role

"Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)" in subsystem Restriction-Modification System (EC 3.1.21.3)

Isozymes

Compare fitness of predicted isozymes for: 3.1.21.3

Use Curated BLAST to search for 3.1.21.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385XTV0 at UniProt or InterPro

Protein Sequence (1031 amino acids)

>DZA65_RS04740 HsdR family type I site-specific deoxyribonuclease (Dickeya dianthicola ME23)
MSTIGQRERATQQRLIQFFVKDLGYRYLGRSAGYAGDSNIDTDILSSWLKRRGVSDTLIT
RVLRQLDSAAALGEGKKLYYANKEVYRLLRYGVKEKEGAGEQNQTVWLIDWAHPEANDFA
IADEVTVKGEYSKRPDLVLYVNGIALGVIELKRSSVHVSEGIRQNLDNQKKTFIRNFFTT
MQLVMAGNDTQGLRYGTIETPEKYYLEWKEENTGAYTHKLDFHLSRLCNKSRLLDIVHNY
MAFDVGVKKLCRHNQFFGVEAAKQHIARREGGIIWHTQGSGKSLTMVWLAKWIRENVPNS
RVLIVTDRTELDEQIESVFMGVDEEIYRTSSGNDLIATLNHPNPWLICSLVHKFGRRSEA
EDSAATDDFISELQQSLTKTFRAKGDLFVFVDECHRTQSGKLHNAMTAILPEALFIGFTG
TPLMKKDKKKSVEVFGPYIHTYKFDEAVADGVVLDLRYEARDIDQYLTSEKKVDDWFEAK
TRGLSNLAKTQLKQKWGSMQKLLSSKSRLEQIVNDILLDMDTRQRLMDGRGNAMLVCSSV
YQACKVYEMFSQTDLAGKVAIVTSFRPDAASIKGEETGAGLTEKLFKFSTYRKMLADYFE
QSEEKVAGRIAEFERDVKQRFINEPGQMRLLIVVDKLLTGFDAPSATYLYIDKTMTDHTL
FQAICRVNRLDGEDKEYGYIIDYKDLFRSLDKAITDYTTGAFDDYDQEDVDGLLKNRLEQ
AKLDLDSALEVVRSLCEPVRAPRTLQDYQHYFCGESGENQTALSEKEALRLSFYQNVARL
LRTYASLANEMPEAGYTAEETESIRAEVAEFEKLRYEIKLTGGDLLDMKRFEPAMRHLLD
MYVRADGSEVLMDFEELSLIELIVEKGAAATAALPDEIRNNQDAMAETIENNVRKTIVDE
NPVNPKYYGRMSLLLDELITLRRQNALDYQQYLERIRDLSKQVIRPEQTAGASYPDTMDT
QAKRAFYDNFGHDEVLATRIDTTIRYTKKAEWIGDRFKERELARALREETASYNVNIDDV
LELARKQKEYH