Protein Info for DZA65_RS03025 in Dickeya dianthicola ME23

Annotation: MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 448 transmembrane" amino acids 31 to 50 (20 residues), see Phobius details amino acids 63 to 86 (24 residues), see Phobius details amino acids 101 to 119 (19 residues), see Phobius details amino acids 125 to 148 (24 residues), see Phobius details amino acids 160 to 184 (25 residues), see Phobius details amino acids 190 to 208 (19 residues), see Phobius details amino acids 252 to 274 (23 residues), see Phobius details amino acids 293 to 314 (22 residues), see Phobius details amino acids 326 to 344 (19 residues), see Phobius details amino acids 350 to 371 (22 residues), see Phobius details amino acids 382 to 405 (24 residues), see Phobius details amino acids 412 to 435 (24 residues), see Phobius details PF07690: MFS_1" amino acids 40 to 401 (362 residues), 177.8 bits, see alignment E=1.5e-56 TIGR00881: phosphoglycerate transporter family protein" amino acids 41 to 418 (378 residues), 484.2 bits, see alignment E=1.3e-149

Best Hits

Swiss-Prot: 85% identical to UHPC_ECOLI: Membrane sensor protein UhpC (uhpC) from Escherichia coli (strain K12)

KEGG orthology group: K07783, MFS transporter, OPA family, sugar phosphate sensor protein UhpC (inferred from 97% identity to ddd:Dda3937_03548)

Predicted SEED Role

"Hexose phosphate uptake regulatory protein UhpC" in subsystem Hexose Phosphate Uptake System

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CUA7 at UniProt or InterPro

Protein Sequence (448 amino acids)

>DZA65_RS03025 MFS transporter (Dickeya dianthicola ME23)
MSGFLNIRFLKIPASAPPLADRHVIDETYRYWRRHILLTLYLGYALFYFTRKSFNAAVPE
ILASGLMARTDIGLLATLFYVTYGVSKFLSGIVSDRSNARYFMGIGLLATGVVNILFGFS
SSLWAFAALWMANAFFQGWGAPVCARLLTSWYSRTERGGWWALWNTAHNVGGALIPMVVG
AAALHYGWRVGMMIAGSLAIVAGLFLCWRLRDKPQTLGLPSVGEWRQDALEIAQQQEGAG
LSRREILHKYVFTNPYIWLLACCYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVTMF
ELGGFIGALVAGWGADKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTG
FFVFGPQMLIGMAAAECSHKDAAGAATGFVGLFAYLGASLSGWPLAHIMDVWHWNGFFAV
IAVAAGISALLLLPFLRASSPRAAADVA