Protein Info for DZA65_RS02280 in Dickeya dianthicola ME23

Annotation: FGGY-family carbohydrate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 503 PF00370: FGGY_N" amino acids 6 to 250 (245 residues), 204.1 bits, see alignment E=2.9e-64 PF02782: FGGY_C" amino acids 260 to 449 (190 residues), 119.7 bits, see alignment E=1.4e-38

Best Hits

Swiss-Prot: 43% identical to GLPK_GEOMG: Glycerol kinase (glpK) from Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)

KEGG orthology group: K00864, glycerol kinase [EC: 2.7.1.30] (inferred from 92% identity to ddc:Dd586_0444)

Predicted SEED Role

"Glycerol kinase (EC 2.7.1.30)" in subsystem Glycerol and Glycerol-3-phosphate Uptake and Utilization or Glycerolipid and Glycerophospholipid Metabolism in Bacteria or MLST (EC 2.7.1.30)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.30

Use Curated BLAST to search for 2.7.1.30

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A385XW34 at UniProt or InterPro

Protein Sequence (503 amino acids)

>DZA65_RS02280 FGGY-family carbohydrate kinase (Dickeya dianthicola ME23)
MSRDTIVALDEGTSNVKAVAIDACGRVVARASRPLHLITPHAGWVEQDGEALLAGSFAVV
REVMEQLGAARVAALAVSNQRETVIGWQRDTGRPISPALSWQCSRSAPFCEQLRRDQQEA
AVRAATGLPVAPLFSGSKMRWLLDNTPDGHARAARGEICLGTIDAWLLWHLTGGRQFRCD
LSNAARTQLLNLHRLQWDDDMLALFGIAHAALPELMPSAGEFGVTCGVPGVADGIPILAM
VGDSHAALYGHGLGRAGGVKATYGTGSSVMAPLGVPDTRITTLATTVAWHDGERAVYALE
GNIPHTGDGVAWMLQATGLNRLSEAELAGALQALPASIDSTDGVYFVPALTGAGAPWWNE
RARGVMCGLSRGSGQAHLVRAALEAIAYQIADVVTAMKQHPDFHLNRLMVDGGPTRNAWL
MQFQADLLGCPVARSTTTELSALGAGLLARRTLGRLSDQQLEPLLPTHDSWLPDEARHQR
YQASRQGWQEAVQRTLWQANHHE