Protein Info for DZA65_RS01445 in Dickeya dianthicola ME23

Annotation: HTH-type transcriptional activator AaeR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 314 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details PF00126: HTH_1" amino acids 4 to 63 (60 residues), 70.9 bits, see alignment E=7.1e-24 PF03466: LysR_substrate" amino acids 89 to 292 (204 residues), 122 bits, see alignment E=2.3e-39

Best Hits

Swiss-Prot: 83% identical to AAER_ECOL6: HTH-type transcriptional activator AaeR (aaeR) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: None (inferred from 97% identity to dze:Dd1591_3828)

Predicted SEED Role

"LysR family transcriptional regulator QseA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A3A4CWT4 at UniProt or InterPro

Protein Sequence (314 amino acids)

>DZA65_RS01445 HTH-type transcriptional activator AaeR (Dickeya dianthicola ME23)
MERLKSMSVFARVVEFGSFTAAARQLAMSVSAVSQTVTRLEDELQVKLLNRSTRSIGLTE
AGRIYYHGCRRMLHEAQEVHEQLYAFNNTPIGTLRIGSSSTMAQNVLATMTTDMLKEYPG
LSVNLVCGIPAPDLIADGLDIVIRVGALQDSSLYSTRLGAMPMVVCAAKSYLAQHATPEK
PADVSNVSWLEYSVRPDSEFELIAPEGITTRLTPQGRFVTNDPVTLIRWLKNGAGIAYVP
LMWVFEEIKRGEIEILFSRYHSDPRPVYALYTRRDNLPLKVQVCINYLTEYFNKVALIYQ
GYRQEHPQAEPPQK