Protein Info for DZA65_RS00310 in Dickeya dianthicola ME23

Annotation: xylose isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02630: xylose isomerase
  • amino acids 4 to 437 (434 residues), 714.6 bits, E=2.2e-219
• PF27526: XylA2_C
  • amino acids 383 to 437 (55 residues), 74.3 bits, 3.7e-25

Best Hits

Swiss-Prot: 88% identical to XYLA_PECAS: Xylose isomerase (xylA) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K01805, xylose isomerase [EC: 5.3.1.5] (inferred from 97% identity to ddc:Dd586_0071)

MetaCyc: 82% identical to xylose isomerase (Escherichia coli K-12 substr. MG1655)
Xylose isomerase. [EC: 5.3.1.5]

Predicted SEED Role

"Xylose isomerase (EC 5.3.1.5)" in subsystem Xylose utilization (EC 5.3.1.5)

MetaCyc Pathways

• superpathway of glucose and xylose degradation (16/17 steps found)
• D-xylose degradation I (2/2 steps found)
• superpathway of pentose and pentitol degradation (12/42 steps found)

KEGG Metabolic Maps

• Fructose and mannose metabolism
• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.5

Sequence Analysis Tools

See A0A3A4D6A5 at UniProt or InterPro

Protein Sequence (439 amino acids)

>DZA65_RS00310 xylose isomerase (Dickeya dianthicola ME23)
MHAYFDQIEKVRFEGQGSRNPFAFRHYNPDEVILGKRMADHLRFAVCYWHTFCWNGADMF
GAGAFARPWQQSGDALALAKRKADIAFEFLHKLGAPYYCFHDVDVAPEGGSLQEYLNNFA
AMTEVLAAKQQETGVKLLWGTANCFTNPRYAAGAATSPDPDVFAWAATQVFTAMNATKTL
GGENYVLWGGREGYETLLNTDLRQEREQIGRFMQMVVEHKHKIGFNGTLLIEPKPQEPTK
HQYDYDVATVYGFLKQFGLEKEIKVNIEANHATLAGHTFHHEIATAIALGIFGSVDTNRG
DPQLGWDTDQFPNSVEENALVLYEILKAGGFTTGGLNFDAKVRRQSTDRYDLFHAHIGAM
DTLALSLKVAARMLEDGELNQQVANRYAGWNSELGQQILQGNASLEMLAGYAVRHQLDPQ
HHSGQQERLENLVNRYLFG