Protein Info for DZA65_RS00150 in Dickeya dianthicola ME23
Annotation: glucokinase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 73% identical to GLK_YERE8: Glucokinase (glk) from Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
KEGG orthology group: K00845, glucokinase [EC: 2.7.1.2] (inferred from 97% identity to ddd:Dda3937_01026)MetaCyc: 71% identical to glucokinase (Escherichia coli K-12 substr. MG1655)
Glucosamine kinase. [EC: 2.7.1.8]; Hexokinase. [EC: 2.7.1.8, 2.7.1.1, 2.7.1.2]
Predicted SEED Role
"Glucokinase (EC 2.7.1.2)" in subsystem Entner-Doudoroff Pathway or Glycolysis and Gluconeogenesis (EC 2.7.1.2)
MetaCyc Pathways
- homolactic fermentation (12/12 steps found)
- glycolysis III (from glucose) (11/11 steps found)
- glycogen degradation I (8/8 steps found)
- Bifidobacterium shunt (13/15 steps found)
- heterolactic fermentation (15/18 steps found)
- sucrose degradation III (sucrose invertase) (4/4 steps found)
- glucose and glucose-1-phosphate degradation (4/5 steps found)
- sucrose biosynthesis II (6/8 steps found)
- UDP-N-acetyl-D-galactosamine biosynthesis II (5/7 steps found)
- GDP-α-D-glucose biosynthesis (2/3 steps found)
- trehalose degradation V (2/3 steps found)
- UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
- glycogen degradation II (4/6 steps found)
- trehalose degradation I (low osmolarity) (1/2 steps found)
- trehalose degradation II (cytosolic) (1/2 steps found)
- 1,3-propanediol biosynthesis (engineered) (6/9 steps found)
- trehalose degradation IV (1/3 steps found)
- chitin biosynthesis (5/9 steps found)
- chitin derivatives degradation (4/8 steps found)
KEGG Metabolic Maps
- Aminosugars metabolism
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Fructose and mannose metabolism
- Galactose metabolism
- Glycolysis / Gluconeogenesis
- Nucleotide sugars metabolism
- Starch and sucrose metabolism
- Streptomycin biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 2.7.1.8
Use Curated BLAST to search for 2.7.1.1 or 2.7.1.2 or 2.7.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A3A4D6D6 at UniProt or InterPro
Protein Sequence (322 amino acids)
>DZA65_RS00150 glucokinase (Dickeya dianthicola ME23) MHQYALVGDVGGTNARLALCELANGQLSHSKQYAVQQHDSLEDAMRLFLAEHASLTIKEA CIAIACPVTDDWVEMTNHHWAFSIAAMRQNLGFERLEVINDFTAVSMAIPVLTPEDVIQL GGADAVAGKPVAVYGAGTGLGVAHLLPVAGTWLSLPGEGGHVDFASNSEEEDILLQVLRQ ELGHVSAERVLSGPGLVNIYRAIVKADNRVPEALTPQVVSERALAHSDVDCLRALSLFCV LMGRFGGNLALTLGTFGGVYIAGGIVPRFLEFFRNSGFRSAFEDKGRFRDYLADIPVFMI THPQPGLLGAGAYLRQTLGQTL