Protein Info for DDA3937_RS18820 in Dickeya dadantii 3937

Annotation: DNA-3-methyladenine glycosylase 2 family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 454 PF02805: Ada_Zn_binding" amino acids 11 to 72 (62 residues), 99.2 bits, see alignment E=2.2e-32 PF12833: HTH_18" amino acids 108 to 182 (75 residues), 55.7 bits, see alignment E=1e-18 PF06029: AlkA_N" amino acids 199 to 310 (112 residues), 82.4 bits, see alignment E=5.9e-27

Best Hits

KEGG orthology group: K13529, AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC: 3.2.2.21] (inferred from 100% identity to ddd:Dda3937_02177)

Predicted SEED Role

"ADA regulatory protein" in subsystem DNA repair, bacterial

Isozymes

Compare fitness of predicted isozymes for: 3.2.2.21

Use Curated BLAST to search for 3.2.2.21

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SHZ7 at UniProt or InterPro

Protein Sequence (454 amino acids)

>DDA3937_RS18820 DNA-3-methyladenine glycosylase 2 family protein (Dickeya dadantii 3937)
MNDTVLTIWQQARISRDPRFDGTFFVAVKSTGIFCRPICPASLPLEKNVVYYRTRTEAIQ
AGFRPCLRCKPEYAPRFAELDRKQLLPVRIAAAIDSGEHLLSKVEQIADAHFLSSRYLNR
LFREHYGCSVKEYQNIAKIFFAKKLFQSSSLSITDIAASCGFSGLSGFYQLIDKYLKTTP
KRMMLSPSDSRDKTEHIRLRLPVGGRYHWDYFLAFQSRRLIDGVEWIEGATYGRRFILNG
EKGSFQIRPATGGFDVTIALSRLTLLSQVLERIRNLFDLNVNIEAVEDQLRRAYPTLPIV
PGIRIPGVFSPFEAALRAVCGQQVSVSAATTLLNQLVSLCAIEEDGQRYFPTPDRITPEV
VGQLRTMQSKKATLVNIADWFCRHDLSEIDRLTEVKGVGRWTLDYLKLRSLNDPDIWLGG
DLGIRNALRQLGEIDPQRAAPWKSYLTLHLWNTL