Protein Info for DDA3937_RS12565 in Dickeya dadantii 3937

Annotation: pyridoxal kinase PdxY

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00687: pyridoxal kinase
  • amino acids 1 to 285 (285 residues), 413.7 bits, E=2.1e-128
• PF08543: Phos_pyr_kin
  • amino acids 75 to 255 (181 residues), 49.8 bits, E=3.1e-17
• PF00294: PfkB
  • amino acids 138 to 248 (111 residues), 28.5 bits, E=9.9e-11

Best Hits

Swiss-Prot: 84% identical to PDXY_PECAS: Pyridoxal kinase PdxY (pdxY) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K00868, pyridoxine kinase [EC: 2.7.1.35] (inferred from 100% identity to ddd:Dda3937_00091)

MetaCyc: 71% identical to pyridoxal kinase 2 (Escherichia coli K-12 substr. MG1655)
Pyridoxal kinase. [EC: 2.7.1.35]

Predicted SEED Role

"Pyridoxal kinase (EC 2.7.1.35)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 2.7.1.35)

MetaCyc Pathways

• superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (12/12 steps found)
• pyridoxal 5'-phosphate salvage I (6/6 steps found)
• pyridoxal 5'-phosphate salvage II (plants) (8/9 steps found)
• 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis II (5/8 steps found)

KEGG Metabolic Maps

• Vitamin B6 metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.35

Sequence Analysis Tools

See E0SG19 at UniProt or InterPro

Protein Sequence (286 amino acids)

>DDA3937_RS12565 pyridoxal kinase PdxY (Dickeya dadantii 3937)
MKNILSIQSHVVFGHAGNSAAEFPMRRMGVNVWPLNTVQFSNHTQYGQWTGCVMPAEHLT
EIAQGISNIDHLKDCDAVLSGYIGSPEQGGHILEVVRRVKAANPRAIYFCDPVMGTPEKG
CIVPAGVTDFHCNQSLLASDMIAPNLPELELLSGRTVHTVDEAVQASRELCRRGPKLVLV
KHLSRAAASKDSFEMLLVTPEDAWHIQRPLVDFGPRQPVGVGDLTSGLLLVNLLKGVAPE
KALEHTTAAVYEVMLVTKEMEQYELQLVAAQDGIVQPRHHFQAVRL