Protein Info for DDA3937_RS11070 in Dickeya dadantii 3937

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 460 PF11563: Protoglobin" amino acids 12 to 164 (153 residues), 84 bits, see alignment E=1.7e-27 PF21118: DosC_2nd" amino acids 185 to 292 (108 residues), 146.3 bits, see alignment E=6e-47 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 299 to 458 (160 residues), 173 bits, see alignment E=2.2e-55 PF00990: GGDEF" amino acids 301 to 455 (155 residues), 160.6 bits, see alignment E=4.1e-51

Best Hits

KEGG orthology group: K13069, diguanylate cyclase [EC: 2.7.7.65] (inferred from 100% identity to ddd:Dda3937_02950)

Predicted SEED Role

"Putative Heme-regulated two-component response regulator" in subsystem Putative hemin transporter or cAMP signaling in bacteria

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.65

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SCN2 at UniProt or InterPro

Protein Sequence (460 amino acids)

>DDA3937_RS11070 diguanylate cyclase (Dickeya dadantii 3937)
MHTEQSDNNELLLAEWQELVNLTSSDAHELLRDLCEEELRQLVSVFYDYMLQDKKASLYL
NTQQVANQLNESMYHWLRSVLGSATESLSALLERQQQVGVIHARIGIPTDLVARGARKLK
NELFRLLDRKRNLDAALINQAVCFSSLVIDTAIEAMTTAYSPGYKSAMRDQERYRILSIY
DDVNVERERQLGALMNWENQFIYNVATGLPSEEIVLLEKSEFGLWFFHKGRHLFNGPDLL
KKLEALIRQVDNRVRETFPHHVENTAIRTQLLRDVRQLVGQVNSILCSMFDELIKFENGK
DPLTNLLNRRFIPTIMRREIALAISSGKPFILAMIDIDHFKKINDNYGHETGNLTLKTIA
TKIYESVRSSDYVFRYGGEEFMVLLVETQTSQAAMIFDSIRQLIAGLYIPATAEKGISVT
ISVGIAEFDNHPDYQQLIKKADNALYQAKANGRNRIEIFG