Protein Info for DDA3937_RS10805 in Dickeya dadantii 3937

Annotation: serralysin family metalloprotease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 481 PF00413: Peptidase_M10" amino acids 103 to 203 (101 residues), 35 bits, see alignment E=4.5e-12 PF13688: Reprolysin_5" amino acids 113 to 230 (118 residues), 27.5 bits, see alignment E=1.2e-09 PF05572: Peptidase_M43" amino acids 139 to 210 (72 residues), 26.3 bits, see alignment E=2.2e-09 PF13583: Reprolysin_4" amino acids 170 to 231 (62 residues), 26.9 bits, see alignment E=1.3e-09 PF08548: Peptidase_M10_C" amino acids 262 to 481 (220 residues), 296.7 bits, see alignment E=3e-92 PF00353: HemolysinCabind" amino acids 346 to 381 (36 residues), 34.2 bits, see alignment 7.1e-12 amino acids 365 to 397 (33 residues), 35 bits, see alignment (E = 3.8e-12)

Best Hits

Swiss-Prot: 100% identical to PRTB_DICCH: Serralysin B (prtB) from Dickeya chrysanthemi

KEGG orthology group: None (inferred from 100% identity to ddd:Dda3937_04583)

Predicted SEED Role

"Secreted alkaline metalloproteinase (EC 3.4.24.-), PrtA/B/C/G homolog" in subsystem Protein secretion by ABC-type exporters (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SC30 at UniProt or InterPro

Protein Sequence (481 amino acids)

>DDA3937_RS10805 serralysin family metalloprotease (Dickeya dadantii 3937)
MQQNEKASLNTSAAAAKAGSYTGYADVYDFWYYHQRGDGLTVNGKPSYTTDKAVSEGLTR
PHTTWNGDNVFGKAANLTYSFLNTFSSTPNGHTGPVKFTPVQMQQAKLSLQSWADAANLT
FTEVSPNQKANITFANYTRNADGSLNTDTQAYAAYPGTHPVSGSAWFNYNQSSIRNPDTD
EYGRHSFTHEIGHALGLSHPAEYNAGEGDISYKNSAAYAEDSRQFSIMSYWEVENTGGDF
KGHYSAGPLMDDIAAIQKLYGANMTTRTGDTVYGFNSNTDRDFYTATNSSKALVFSVWDA
GGNDTFDFSGYSNNQRINLNEGSFSDVGGLKGNVSIAHGVTIENAIGGSGNDILIGNGAD
NILQGGAGDDVLYGSTGADTLTGGAGRDIFVYGSGQDSTVSAYDWITDFQTGIDKIDLSA
FRNEGQLSFVQDQFTGKGQEVMLQWDAANSTTNLWLHEAGHSSVDFLVRIVGQTAQSDII
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