Protein Info for CCNA_02024 in Caulobacter crescentus NA1000 Δfur

Annotation: NADH-quinone oxidoreductase chain F

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01959: NADH oxidoreductase (quinone), F subunit
  • amino acids 11 to 420 (410 residues), 633.1 bits, E=7e-195
• PF01512: Complex1_51K
  • amino acids 51 to 219 (169 residues), 164.6 bits, E=1.6e-52
• PF10589: NADH_4Fe-4S
  • amino acids 336 to 418 (83 residues), 110 bits, E=4.1e-36

Best Hits

Swiss-Prot: 75% identical to NUOF1_RHIME: NADH-quinone oxidoreductase subunit F 1 (nuoF1) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K00335, NADH dehydrogenase I subunit F [EC: 1.6.5.3] (inferred from 100% identity to ccs:CCNA_02024)

MetaCyc: 74% identical to NADH-ubiquinone oxidoreductase 51 kDa subunit (Arabidopsis thaliana col)
NADH-DEHYDROG-A-RXN [EC: 7.1.1.2]

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain F (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

• NADH to cytochrome bd oxidase electron transfer I (2/2 steps found)
• NADH to cytochrome bo oxidase electron transfer I (2/2 steps found)
• aerobic respiration I (cytochrome c) (3/4 steps found)
• aerobic respiration III (alternative oxidase pathway) (2/3 steps found)
• Fe(II) oxidation (3/6 steps found)
• NAD(P)/NADPH interconversion (3/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3 or 7.1.1.2

Sequence Analysis Tools

See A0A0H3C9B9 at UniProt or InterPro

Protein Sequence (439 amino acids)

>CCNA_02024 NADH-quinone oxidoreductase chain F (Caulobacter crescentus NA1000 Δfur)
MVGILEDKDRIFTNLYGLHDWGLEGAKKRGCWNGTKDILDAGRDWIIENMKNSGLRGRGG
AGFSTGLKWSFMPKEVKDGRPHYLVVNADESEPGTCKDREIMRHDPHLLIEGCLIASRAM
LAHACYIYIRGEYVFERERLEAAIKQAYEAKLVGKNNVHGWDFDIYVHHGAGAYICGEET
ALLESLEGKKGQPRLKPPFPAGAGLYGMPTTVNNVESIAVAGTILRRGAAWFAGFGRPNN
AGTKLFCVSGHVNLPCNVEEAMSIPFRQLVEDHCGGIRGGWGNLKAVIPGGSSVPMIPAE
QCEDLPMDFDALRNLKSGLGTAAVIVMDKDTDLVRAIARLSYFYKHESCGQCTPCREGTG
WMWRVMERMVTGEADPKEIDTLLDVTTQVEGHTICALGDAAAWPIQGLFRHFRHEVEERI
ASYRSGRLHVQGAKLIAAE