Protein Info for CCNA_01262 in Caulobacter crescentus NA1000 Δfur

Annotation: cation/multidrug efflux pump, AcrB family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1047 transmembrane" amino acids 12 to 29 (18 residues), see Phobius details amino acids 334 to 353 (20 residues), see Phobius details amino acids 360 to 380 (21 residues), see Phobius details amino acids 386 to 410 (25 residues), see Phobius details amino acids 431 to 452 (22 residues), see Phobius details amino acids 459 to 481 (23 residues), see Phobius details amino acids 523 to 547 (25 residues), see Phobius details amino acids 859 to 878 (20 residues), see Phobius details amino acids 887 to 907 (21 residues), see Phobius details amino acids 917 to 937 (21 residues), see Phobius details amino acids 959 to 981 (23 residues), see Phobius details amino acids 990 to 1013 (24 residues), see Phobius details PF00873: ACR_tran" amino acids 3 to 1016 (1014 residues), 952.1 bits, see alignment E=3.5e-290 PF02355: SecD_SecF_C" amino acids 325 to 484 (160 residues), 23.5 bits, see alignment E=3.4e-09

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 100% identity to ccs:CCNA_01262)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C7I8 at UniProt or InterPro

Protein Sequence (1047 amino acids)

>CCNA_01262 cation/multidrug efflux pump, AcrB family (Caulobacter crescentus NA1000 Δfur)
MLSDLSVRRPVFAAVAAIILCVIGLAAYTSLPIRELPSVDPPVVSVSTSYRGASAEVIEE
RITQVIERQVAGIQGIDRVNSSSRDGRSNISITFNLDRDLDAAANDVRDAVSRVTSNLPD
QADPPQIAKANADAAPIIILNLTSTTLNPLQLADYADRYLVERMSTVDGVAQANLFGAKI
YAMRIWLDANEMAARGVTVDDVESALNAQNLELPAGSLESAAKDFTIRVARSYATPEEFA
RLPLRAANSSGYVLRLGDVARIEEGPDERRRLFRGNGIDQVGIGLTRQSQANDVAISKAV
RAEVEAINQTLPPGTKMVIAVDNSVFTAEAIHEVWITMGLAIGLVVMVNLLFLGSWRSAL
IPSIVAPICILSTFIILAPLGFSLNLLTLLALVLAVGLVVDDAIVVVENIQRRVDDGEPP
LVAAERGTRQVFFAVVATTVVLVSVFAPLMFLPGYIGRLFVELAVAIAAAVAFSALLALS
LSPMMASKLLRPAHGEGWLARRVNKTMGALSASYRASLEQILGGWSAAASGVLVVLLAGF
AAVLFVSLPKELVPAEDRGRVDVSISAAEGAGYDYTSAIALKIEKVLDKYREAGVSERTI
MTIPRFGGNSFNSANGVVALKPWGERDKTADEVAAELNKELSRFTSVRAVASVRGPFQRG
GGGGGGGGTNVDFIAVGNDYVQLANWLKPILAEAQDNPGLARPRLDYEPTAPRLLVQIDL
DKAATLGVSAQSVGRALETMFGSRRATTYIKSGQEYDVILQTNLDQRRSIEDLNRLNVRT
NTGAIVPLSTVVTTELRGDTPDRPRVDRLRSVTLTAQLNPGYTVEDAVAFFKDQAAQHPA
PGVSVKWGGQAKDYLEGSGGIAIAFGLALLLVFLVLAAQFESWIHPAVIMLTVPLAALGG
LFGLLMTGSTINTYSQIGLIILIGIATKNGILIVEFANQLRDEGLSVREAVIEAAALRLR
PIIMTSVSAAMGALPLMLWAGAGAGSRQTIGAVIFTGAIFATLLTLFIVPVFYDLLARFT
KSPEWTARQIEAYEAQEKSGEGQTSPA