Protein Info for B158DRAFT_2462 in Kangiella aquimarina DSM 16071

Annotation: heavy metal efflux pump (cobalt-zinc-cadmium)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1042 signal peptide" amino acids 10 to 13 (4 residues), see Phobius details amino acids 30 to 31 (2 residues), see Phobius details transmembrane" amino acids 14 to 29 (16 residues), see Phobius details amino acids 338 to 358 (21 residues), see Phobius details amino acids 364 to 384 (21 residues), see Phobius details amino acids 390 to 411 (22 residues), see Phobius details amino acids 444 to 463 (20 residues), see Phobius details amino acids 482 to 503 (22 residues), see Phobius details amino acids 533 to 552 (20 residues), see Phobius details amino acids 870 to 889 (20 residues), see Phobius details amino acids 896 to 916 (21 residues), see Phobius details amino acids 922 to 946 (25 residues), see Phobius details amino acids 981 to 1001 (21 residues), see Phobius details amino acids 1013 to 1035 (23 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1038 (1038 residues), 1285.9 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1034 (1030 residues), 825.6 bits, see alignment E=2.8e-252

Best Hits

Swiss-Prot: 58% identical to CUSA_ECOLI: Cation efflux system protein CusA (cusA) from Escherichia coli (strain K12)

KEGG orthology group: K07787, Cu(I)/Ag(I) efflux system membrane protein CusA (inferred from 75% identity to alt:ambt_07220)

MetaCyc: 58% identical to copper/silver export system RND permease (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-90; TRANS-RXN0-280

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1042 amino acids)

>B158DRAFT_2462 heavy metal efflux pump (cobalt-zinc-cadmium) (Kangiella aquimarina DSM 16071)
MIASIIRWSIHNRFFVLLATLILVGVGIYSLKKTPVDAIPDLSDVQVIIKTSYPGQAPQV
VEDQVTYPLTTAMLSVPGAQTVRGFSFFGDSYVYVIFDEDTDLYWARSRVLEYLSQVAPS
LPETAKPQLGPDATGVGWVYLYALVDKSGQQDISQLRSIQDWFLKYELQTVDGVSEVATV
GGMVKQYQVKVDPEKLRAYSIPLDLIQRAIQQSNQEVGASVIEMAEAEYMVRASGYLKNQ
EDIGLIPLGVNEQGTPLLLKDVADISVGPQMRRGIAELNGQGETVGGIIVMRFGENAQQT
INAVKDKLAQLQSSLPQGVELVTVYDRSGLIERAVDNLWQKLIEELLIVALVCMVFLFHV
RSSLVAVISLPVGILTAFIIMHWQGLNANIMSLGGIAIAIGTMVDGAIVMIENMHKHLER
ARTEHQTLTSKQRWEVVSQSATEVGPALFFSLLIITASFIPVFTLEAQEGRMFSPLAFTK
TYAMAASAALAITLVPVLMGYFVRGKIRPENKNPINRALSQVYKPVLTRILRFPRTTLGV
IALLMIVGLWPATKIGSEFMPELDEGDLMYMPTTYPGLSIGEAREILQQTDKLIMTVPEV
KTVFGKIGRADTATDPAPLTMIETFIQLKPKNQWREGVTTSSIKQELENLVRIPGLSNAW
VMPIKTRIDMLATGIKTPVGIKVSGPDLSVIESIGKQLEQILQKVPGTASVYSERVAGGR
YLDIDIHREQAARYGLNIKNIQQVISTAVGGMNITQTVEGLERYPVNIRYPQEYRDSPEQ
LALLPIVTPAGQRIALGDVATIQILDGPPAIKSENARINGTVFVDIDNIDIGHYVSQAQQ
VVNEQLELPAGYSLNWAGQYEYMLRAEKKLSYVLPLTLAIIMVLLYLSFRNLMEVIIIMG
TLPLAIVGSLWLTYLMGLNFSVAVWVGFIALAGVAVEIGVIMLVYLNQSYKELIDSSTTK
LDKEQLKQAIIDGASLRVRPIMMTAASIILGLLPILLGGGTGAELMSGIATPMVGGMLSA
LILTLVVLPLVYYLWRARSIQN