Protein Info for B158DRAFT_2428 in Kangiella aquimarina DSM 16071

Annotation: indole-3-glycerol phosphate synthase (EC 4.1.1.48)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00218: IGPS
  • amino acids 24 to 245 (222 residues), 278.2 bits, E=7.9e-87
• PF00697: PRAI
  • amino acids 251 to 453 (203 residues), 141 bits, E=5.9e-45

Best Hits

KEGG orthology group: K13498, indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase [EC: 4.1.1.48 5.3.1.24] (inferred from 71% identity to kko:Kkor_1644)

Predicted SEED Role

"Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)" in subsystem Tryptophan synthesis or Auxin biosynthesis (EC 4.1.1.48, EC 5.3.1.24)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (17/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• L-tryptophan biosynthesis (6/6 steps found)
• superpathway of chorismate metabolism (41/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.48 or 5.3.1.24

Protein Sequence (486 amino acids)

>B158DRAFT_2428 indole-3-glycerol phosphate synthase (EC 4.1.1.48) (Kangiella aquimarina DSM 16071)
MLNVLETILQHKREVIGNTPDFSTLTPSQRSFYDALSQPHYGFIMECKKASPSKGLIRGN
FDIEEIVSVYDQYADAISVLTEERFFRGSFSNLAKARQLTDKPILCKDFIFTPKQIRQAR
HFGADAVLLMLSVLNDRDYQICHEQATSLNMDVLTEVHTEAELERAILLGAKIIGINNRN
LKDLSTSFEHTKQLVDKIPGDRLIITESGISTHSDVLELSRFSDACLVGSSLMKEADLEC
AARQLVYGDIKVCGVTQQADITMLETLPVSSVGIIFAPSSKRRVSETIKTSQKPLVGVFQ
NQETDEVVSKALNYQLNAIQLHGDETLEYAEAIRQKLPTVKLSKVFHVSSDVSKDELVNE
LEDLLEHYDEILLDSAICDGEQLQRGGTGVTFDWSLIQSLKPELLRQKIRIAGGVSSANI
QQLKQMGITKLDISSSVESSPGFKSQDLLTDFFLSARPQSGRNSINSIVTELDRQSTAVA
ATGVSS