Protein Info for B158DRAFT_2160 in Kangiella aquimarina DSM 16071

Annotation: sulfite reductase (NADPH) alpha subunit (EC 1.8.1.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01931: sulfite reductase [NADPH] flavoprotein, alpha-component
  • amino acids 23 to 613 (591 residues), 668.5 bits, E=4.9e-205
• PF00258: Flavodoxin_1
  • amino acids 73 to 201 (129 residues), 98.9 bits, E=4.7e-32
• PF00667: FAD_binding_1
  • amino acids 248 to 439 (192 residues), 97.2 bits, E=1.6e-31
• PF00175: NAD_binding_1
  • amino acids 471 to 577 (107 residues), 64.6 bits, E=1.9e-21

Best Hits

KEGG orthology group: K00380, sulfite reductase (NADPH) flavoprotein alpha-component [EC: 1.8.1.2] (inferred from 65% identity to kko:Kkor_0726)

Predicted SEED Role

"Sulfite reductase [NADPH] flavoprotein alpha-component (EC 1.8.1.2)" in subsystem Cysteine Biosynthesis (EC 1.8.1.2)

MetaCyc Pathways

• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• superpathway of L-methionine biosynthesis (by sulfhydrylation) (10/12 steps found)
• assimilatory sulfate reduction I (4/4 steps found)
• assimilatory sulfate reduction III (3/3 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (8/10 steps found)

KEGG Metabolic Maps

• Sulfur metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.2

Use Curated BLAST to search for 1.8.1.2

Protein Sequence (613 amino acids)

>B158DRAFT_2160 sulfite reductase (NADPH) alpha subunit (EC 1.8.1.2) (Kangiella aquimarina DSM 16071)
MTVKEQLLNGLSGALINTELLDSIRNLNPQQLNWLSGYCAGLLAYQSENQAETEVANLTV
SSHASQAAKPVLVLYASQTGNAQSVAEQLIDRLHSSSVTAELKSTLAVSAKELVDYSTIL
LVTSTHGEGEPPDDAVDFYDELTSKKLLSKKQLLAGIDIAVLGLGDSSYEFFCQTAKDML
DSFKKLGAQELTEIVLCDVDFEPAAKQWIDQVAAAVIAKGKELKTGKDASKIAIDSIDSI
VRNEKINYDKENPFTASIATIQRITGRGSSKETYHLEIDITGSGILYEPGDALGIIAHNR
SELVSDIIELLHLSGDTQVKYRNQQLTLIQFLTEVAELTLINKGTVQALIELTQSDALKK
RVKNNFKSYVKDHQLIDVLLIAKPKISAQHLVDILKPKKPRLYSIASSQRENPDEIHLTL
NHILIKNQNGIRYGLASHYLTQQFEEGQSVNIFVERNPKFKLPSTDSPIIMVGPGTGIAP
FRAFLQERAAKNSAGKNWLLFGNPHFNTDFLYQVEIQKYVNSGVLNKLHLAFSRDSDQKV
YVQHKLLENSAEVWQWLEQGAYFYVCGDMHKMAKDVEKVLLSIIQQQGKYSLDEAKQYFK
DLKVQQRYQRDVY